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Simethicone and Dicyclomine syrup

Simethicone and Dicyclomine syrup is used to treat infant colic, abdominal pain and wind in adults and children. Learn how to use the medication, its common side effects, special precautions to watch out for, and more.
  • Article last reviewed 12 June 2026
  • 6 mins read

What is this medication for?

This medication is used to treat infant colic, abdominal pain, and wind in adults and children. Colic happens when a perfectly healthy baby cries heavily and frequently for long periods, with no clear reason. It may be accompanied by bowel movement and passing gas. Dicyclomine helps to reduce muscle spasms and cramps in the abdomen by relaxing the muscles. Simethicone helps to reduce wind by making it easier to pass out of your body.

How should I take or use this medication?

  • Take this medication as recommended by your healthcare professional. Consult your healthcare professional if you are not sure how to take this medication correctly.
  • Do not use it in infants under the age of six months.

What should I do if I forget to take or use this medication?

It may be taken when required for a short period of time. This means you no longer have to take them if you do not have any more symptoms. If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue normally. Do not take two doses or extra medication to make up for the missed dose.

What precautions should I take when taking or using this medication?

Inform your healthcare professional if: 

  • You are allergic to this medication or any of the other ingredients of this medication.
  • You are pregnant, planning to become pregnant, or breastfeeding.
  • You are taking any other medications (such as Levothyroxine, antidepressants, antipsychotics), including supplements, traditional medications, and herbal remedies.
  • You have any medical conditions such as glaucoma, enlarged prostate, urinary retention (having trouble passing urine), tachycardia (fast heartbeat), heart failure, paralytic ileus (intestine blockage), ulcerative colitis (long-term inflammation and ulcers in the colon), pyloric stenosis (narrowing of the opening between the stomach and the small intestine), kidney disease or liver disease.

If you have any questions about this medication, please discuss with your healthcare professional.  

What are some common side effects of this medication? ​

Dry mouth, thirst and dizziness may occur.

  • These side effects should go away after a few days.

What are some rare but serious side-effects that I need to seek medical advice immediately? 

The symptoms of a drug allergy include one or more of the following:  

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

You can also find out about drug allergies by watching these videos:

For videos in 中文, Melayu and தமிழ், click here

What food or medication should I avoid when I take or use this medication?

  • Levothyroxine may be less effective if taken with this medication as less Levothyroxine may be absorbed. If you need to take this medication with Levothyroxine, take the medications four hours apart from each other.
  • Other medications such as antidepressants and antipsychotics may also interact with this medication. Please inform your healthcare professional if you are taking any other medications.

How should I store this medication?

Store in a cool and dry place, away from direct sunlight. Keep this medication away from children. 

How do I throw away this medication safely? ​

Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin.

Disclaimer

Please take note that the above is not a complete list of all possible side-effects. If you have any concerns about your medication or if you have other side-effects that you think are caused by this medication, please consult your doctor or pharmacist. If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information. 

This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (NHG Health, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.