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Simethicone (simeticone)

Simethicone is used to relieve discomfort caused by excess gas in the stomach and intestines in infants, children and adults. Learn how to use the medication, its common side effects, special precautions to watch out for, and more.
  • Article last reviewed 10 November 2026
  • 6 mins read

What is this medication for?

Simethicone works by breaking up gas bubbles in the stomach and intestines, making it easier for gas to be passed out of the body. This helps to relieve discomfort caused by excess gas, such as bloating, a feeling of fullness, and passing gas or wind (flatulence). 

Simethicone or simethicone-containing medication is commonly used in infants to relieve infant colic (a condition where babies cry excessively due to tummy discomfort from trapped wind).

Simethicone may also be used before certain medical procedures such as gastroscopy (a procedure where a camera is used to examine the digestive tract) to reduce gas bubbles that may interfere with the procedure.

It may also be used for other indications as prescribed by your doctor.

How should I take or use this medication?

Simethicone can be a standalone medication or could be combined with antacids or anti-spasmodic medications in a single dosage form. 

You may take simethicone with or without food.

For liquid dosage forms (drops/suspension):

  • Shake the bottle well before use.
  • Measure the dose carefully using the measuring device provided.
  • You may mix the drops with a small amount of water, infant formula, or other suitable liquid if instructed to do so. For infants, taking simethicone before each feed help with burping.

What should I do if I forget to take or use this medication?

Simethicone is mostly taken when required for a short period of time. This means that you do not have to take it if you do not have any symptoms. If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue normally. Do not take two doses or extra medication to make up for the missed dose. 

What precautions should I take when taking or using this medication?

Inform your healthcare professional if:

  • You are allergic to this medication or any of the other ingredients of this medication.
  • You are pregnant, planning to become pregnant, or breastfeeding.
  • You are taking any other medications, including supplements, traditional medications and herbal remedies.
  • You have any other medical conditions.

If you have any question about this medication, please discuss with your healthcare professional.

What are some common side effects of this medication? ​

Simethicone is generally well tolerated. It is not significantly absorbed into the body and side effects are uncommon.

If you experience any side effects that concern you, please consult your doctor or pharmacist.

What are some rare but serious side-effects that I need to seek medical advice immediately? 

The symptoms of a drug allergy include one or more of the following:

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

You can also find out about drug allergies by watching these videos:

For videos in 中文, Melayu and தமிழ், click here

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

What food or medication should I avoid when I take or use this medication?

There are no known significant food or drug interactions with Simethicone at this time. However, always inform your doctor or pharmacist of all medications, supplements and herbal remedies you are taking.

How should I store this medication?

Store in a cool and dry place, away from direct sunlight. Keep this medication away from children.

How do I throw away this medication safely? ​

Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin.

Disclaimer

Please take note that the above is not a complete list of all possible side-effects. If you have any concerns about your medication or if you have other side-effects that you think are caused by this medication, please consult your doctor or pharmacist. If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information. 

This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (NHG Health, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.