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How To Dissolve Sachets

This article explains how to administer half or a full sachet for some medications. 
  • Article last reviewed 23 July 2026
  • 3 mins read

How should I take or use this medication?

How To Dissolve Sachets

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Step 1: If you are directed to use half a sachet, remember to flatten the sachet first to ensure that the medicine is evenly distributed.

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Step 2: Fold the sachet into half.

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Step 3: Tear or cut the top of the sachet.

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Step 4: Pour approximately half the content or the whole content, depending on the dose indicated on the medication label, into a cup.

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Step 5 : Add water into the cup. Water should be boiled and cooled down to room temperature.

  • Acetylcysteine granules
    • Use a small quantity of water
  • Sodium zirconium cyclosilicate granules
    • Use approximately 45mL of water
  • Cholestyramine, Ispaghula husk, Fosfomycin, urinary alkalizer powders (e.g. Ural®)
    • Use a full cup of water (approximately 200-250mL)
  • Macrogol 4000
    • Use a full cup of water (approximately 200-250mL) for one sachet or half cup of water for half a sachet.
    • You may also use other beverages such as fruit juices or milk for dissolving Macrogol powder, but do not use soda as it may cause stomach discomfort in some patients.
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Step 6: Stir to dissolve/disperse the powder.

(make sure you stir the powder again if the powder settles before drinking)

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Step 7: Drink the entire solution in the cup. You may use a syringe to administer the solution to younger children, if needed.