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Dextromethorphan

Dextromethorphan is used to reduce the urge to cough. Learn how to use the medication, its common side effects, special precautions to watch out for, and more.
  • Article last reviewed 11 November 2025
  • 6 mins read

What is this medication for?

Dextromethorphan is a cough suppressant that works by reducing the urge to cough. It may be found in the form of a liquid, tablet or lozenge. It may also be found in combination with other ingredients for the relief of runny nose, blocked nose or phlegm.  

How should I take or use this medication?

  • Take this medication as recommended by your healthcare professional. Consult your healthcare professional if you are not sure how to take this medication correctly.
  • This medication may be taken with or without food.
  • For syrups, shake the bottle well before use.
  • If your symptoms do not go away or worsen after one week of taking this medication, please speak to your healthcare professional. 

What should I do if I forget to take or use this medication?

Dextromethorphan may be taken when required for a short period of time. This means that you do not have to take it if you do not have any symptoms. If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue normally. Do not take two doses or extra medication to make up for the missed dose. 

What precautions should I take when taking or using this medication?

Inform your healthcare professional if:

  • You are allergic to this medication or any other ingredients used in this medication. 
  • You are taking any other medications, including supplements, traditional medications and herbal remedies.
  • You have a history of asthma or lung diseases.
  • You are a smoker or have recently taken steps to quit smoking. 

What are some common side effects of this medication? ​

  • Drowsiness or dizziness
    • Avoid driving, operating machinery or other activities which require concentration, if affected.
  • Nervousness
  • Restlessness
  • Nausea
  • Vomiting
  • Stomach pain

These side effects are usually mild and will pass quickly. If the side effects are bothersome, do not go away or worsen, speak to your healthcare professional. 

What are some rare but serious side-effects that I need to seek medical advice immediately? 

The symptoms of a drug allergy include one or more of the following:

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

You can also find out about drug allergies by watching these videos:
They are available in English, 中文, Melayu and தமிழ்: Drug Allergies

Signs that your condition may require further medical attention include:

  • Cough with thick, yellow or green phlegm or mucus
  • Cough with bloody or pink frothy phlegm or mucus
  • Fever more than 38.6oC
  • Wheezing or shortness of breath
  • Chest pain
  • Swelling at the legs or ankles
  • Unintended weight loss
  • Drenching night sweats
  • Cough lasting for longer than three to four weeks
  • Cough that happens after starting a new medication
  • Having new symptoms during self-treatment

If you experience any of these symptoms, you should stop this medication and see your doctor immediately. 

What food or medication should I avoid when I take or use this medication?

Let your healthcare professional know if you are taking or planning to take any of the following medications for mood disorders:

How should I store this medication?

Store in a cool and dry place away from direct sunlight. Keep this medication away from children.  

How do I throw away this medication safely? ​

Pack this medication into a black trash bag and seal it tightly before throwing it into the rubbish chute or bin. 

Disclaimer

Please take note that the above is not a complete list of all possible side-effects. If you have any concerns about your medication or if you have other side-effects that you think are caused by this medication, please consult your doctor or pharmacist. If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.

This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (NHG Health, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.