Medication Information Leaflet
Crizotinib is used to treat non-small cell lung cancer that has spread to other parts of the body. Your doctor will check for a gene mutation before starting you on this medication.
Take Crizotinib two times a day.
You may take it with or without food.
Do not break open or crush the capsules. Swallow the capsule whole.
If you forget to take a dose, take it as soon as you remember. However, if it is less than 6 hours to your next dose, skip the missed dose and take your next dose at the usual time. Do not take two doses at the same time.
If you vomited after taking a dose, do not take another dose. Take your next dose at the usual time.
Inform your healthcare professional if:
You are allergic to this medication or any of the other ingredients of this medication.
You are or your partner is pregnant or planning for pregnancy. You should use effective birth control during and for at least:
90 days after stopping treatment (for men)
45 days after stopping treatment (for women)
You are breastfeeding.
You are taking any other medications, including supplements, traditional medications and herbal remedies.
You have any other medical conditions (e.g. heart, eye, liver or kidney problems).
Nausea and vomiting, decreased appetite
Diarrhea or constipation
To manage diarrhea:
Drink plenty of clear fluids to replace those lost (2 litres everyday).
Avoid oily, spicy food or milk and dairy products.
To manage constipation:
Drink more water or clear fluids (unless you have a limit on the amount of fluids you can take each day).
Add more fibre to your diet by eating more fruits and vegetables.
Feeling tired and lack of energy
Swelling of the hands or feet
Numbness or tingling feeling in the hands or feet
Eyesight problems e.g. flashes of light, blurred or double vision, light sensitivity, floaters
Decreased white blood cells
This may put you at higher risk of having infections.
Avoid crowds and people who are sick. Wear a face mask when you are going out.
Wash your hands with soap frequently especially after using the toilet and before handling food.
Symptoms of a drug allergy including one or more of the following:
Difficulty in breathing
Itchy skin rashes over your whole body
Signs of infection - fever of 38°C and above, chills, cough, sore throat, pain or burning feeling on passing urine
Sudden onset or worsening of cough, chest pain or shortness of breath, with fever
Dark urine or light coloured stools, nausea, vomiting, loss of appetite, stomach pain, yellowing of your eyes or skin
Unusual bleeding, bruising, black sticky stools or blood in urine
Rapid or abnormal irregular heartbeat
Unusual onset of weakness, tiredness or light-headedness
Any loss of eyesight
If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.
Avoid taking grapefruit and its juice when you are taking this medication as it may interact with your medication and increase the risk of side-effects.
Store in a cool and dry place, away from direct sunlight. Keep this medication away from children.
Pack Crizotinib into a bag and bring it back to the pharmacy where you received the medication from.
This article was last reviewed on
Wednesday, November 22, 2023
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