Lubiprostone

Medication Information Leaflet

​What is this medication for?

Lubiprostone is used to treat constipation. 

How should I take/use this medication?

  • Do not stop taking your medication without checking with your healthcare professional.
  • You may take this medication with food and water. 
  • Swallow the capsule whole. Do not break apart or chew the capsule.

What should I do if I forget to take/use this medication?

If you forget to take a dose, take it as soon as you remember. Then take your next dose at the usual time. Do not take two doses to make up for the missed dose. 

What precautions should I take?

Inform your healthcare professional if: 
  • You are allergic to this medication or any of the other ingredients of this medication
  • You are pregnant, planning to become pregnant, or breastfeeding 
  • You are taking any other medications, including supplements, traditional medications and herbal remedies. 
  • You have liver disease.

What are some common side-effects of this medication?

  • Nausea
    • Take this medication with food. 
  • Dizziness, fainting or a drop in blood pressure
    • The risk may be increased if you develop diarrhoea or vomiting during treatment. Generally, these side effects go away after some time. 
  • Shortness of breath
    • It may occur especially within an hour of the first dose but generally goes away within three hours. It may happen again with repeated doses. 
  • Other common side effects of this medication include stomach discomfort, headaches, sweating and palpitations.

What are some rare but serious side-effects that I need to seek medical advice immediately?

Consult your healthcare professional if you develop any stomach pain or cramps that does not go away, inability to pass gas or stool, fever, vomiting or diarrhea during the treatment. 

The symptoms of a drug allergy include one or more of the following: 
  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body
If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

What food or medication should I avoid when I take this medication?

Inform your healthcare professional if you are taking or intend to take any other medication, supplements, traditional medications or herbal remedies. 

How should I store this medication?

Store in a cool and dry place, away from direct sunlight. Keep this medication away from children. 

How should I throw away this medication safely?

Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin. 


Disclaimers
If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.


This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (National Healthcare Group, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore.

Last updated on September 2019

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Lubiprostone

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