Sarcoma Cancer: Symptoms, Causes and Treatment

With few known risk factors, sarcoma, a rare cancer of the connective tissue, can be difficult to prevent. Here are some of the common symptoms associated with sarcoma and the treatment options if you are diagnosed with sarcoma.

/sites/assets/Assets/Categories/Chronic%20Illness/sarcoma.jpg?Width=616&Height=275

What is Sarcoma?

Sarcoma is a rare type of cancer that arises in the bone and soft tissue, which includes fat, muscles, blood vessels, nerves and fibrous tissue. Sarcomas can develop in any part of the body, though they are most commonly seen in the arms and legs. 

Sarcoma Causes: Who Is at Risk?

There are very few known risk factors for sarcomas. Some causes and risk factors may include:
Past radiotherapy treatment
Family history of cancer syndromes
Damaged lymphatic system
Some chemicals are also thought to be associated with sarcoma, though this has not been proven. Smoking, diet and exercise are not linked to developing sarcomas.

Sarcoma Symptoms

The signs of sarcoma depend on the site where they arise. Patients with bone sarcoma may experience the following symptoms:
​Bone swelling and pain which tends to worsen at night
Develop fractures after minor trauma as the bone is weakened by the tumour
A new lump that may not necessarily be painful located anywhere in the body that increases in size, and may grow to a large size over time (patients experiencing soft tissue sarcomas)

It is strongly advised to seek medical advice should any of the above occur.​

How to Prevent Sarcoma

​Given the limited risk factors, it is difficult to prevent sarcomas. There are no screening tests, and the best approach is for patients with new lumps, or lumps that are increasing in size, to seek medical attention early. This is especially so for patients who have a strong family history of cancer, or patients with previous radiation therapy treatment.

How is Sarcoma Diagnosed?

​If there are signs and symptoms of sarcoma, your doctor may order some imaging tests. These include plain X-rays, CT scans, ultrasound scans, MRI scans or even PET or bone scans. The test selected depends on the location of the lump.

After the imaging tests are done, a biopsy is needed to confirm the diagnosis of sarcoma. This can either be done as a needle biopsy or a surgical biopsy.

Needle biopsies are done using a core biopsy needle. These remove a 1mm core of tissue from the tumour, and can be done in the clinic or by a radiologist in the radiology centre using imaging guidance. Multiple cores are often needed in order to obtain sufficient tissue for a diagnosis. Fine Needle Aspiration (FNA) biopsies are not frequently used for sarcomas as insufficient tissue is obtained.

Surgical biopsies may be required for some tumours, especially bone sarcomas and large soft tissue sarcomas.

Biopsies have to properly planned and should be performed by experts with experience in soft tissue sarcoma treatment. An improperly performed biopsy may make subsequent removal difficult and may compromise treatment outcomes.

The specimen taken during the biopsy is processed and reviewed by the pathologist. At times, further molecular tests may be required in order to establish the diagnosis.

​Once a diagnosis of sarcoma is made, further imaging investigations may be required to complete the staging of the cancer. This helps to assess the prognosis for the patient.
 

Soft Tissue Sarcoma Treatment 

Based on the diagnosis and staging, the team will then recommend the appropriate treatment. The possible modalities for treatment include surgery, chemotherapy and radiotherapy. The treatment is decided by a multidisciplinary team that includes specialists from all fields involved in patient management.

Radiation Therapy

Radiation therapy makes use of ionising radiation to eradicate cancer cells. It is often used as an adjuvant treatment in support of surgery to further reduce local recurrences of sarcoma. 

When warranted, it is typically given after surgery when risk factors for recurrence are identified, though it can sometimes be given before surgery. After surgery, the operative and pathological findings are discussed at a multidisciplinary tumour board to identify risk factors for recurrence and the need for adjuvant radiation therapy.

Chemotherapy

Chemotherapy is the use of drugs given systemically either into a vein (parenterally) or taken orally to treat cancer. These drugs enter the bloodstream and reach all areas of the body, making this treatment useful for cancer that has spread (metastasised) to other organs.

Depending on the type and stage of sarcoma, chemotherapy may be given as the main treatment, as an adjuvant (addition) to surgery or as neoadjuvant therapy (prior to surgery to downsize the tumour).

The choice of chemotherapy is highly dependent on the type of sarcoma, and usually consists of a combination of several anti-cancer drugs. The need for chemotherapy will be discussed at a multidisciplinary tumour board, based on investigations and pathological reports available.

If you or a loved one show any potential sarcoma symptoms or believe you may be at risk, seek medical advice from your doctor immediately.

MORE A-Z

Cervical Cancer Prevention
Cervical Cancer Prevention

Precancer of the Cervix — Why the Pap Smear is Important

KK Women's and Children's Hospital
X

Share on Facebook now for
Healthpoints

Stroke: About Stroke
Stroke: About Stroke

An introduction to how a stroke occurs.

Stroke Services Improvement Team
X

Share on Facebook now for
Healthpoints

brain-mri-scan
Stroke: Types and Causes

What are the different types of strokes?

Stroke Services Improvement Team
X

Share on Facebook now for
Healthpoints

More A-Z

536
Sarcoma Cancer: Symptoms, Causes and Treatment

 Catalog-Item Reuse

Back to Top