Upadacitinib

What is this medication for?

Upadacitinib is an oral Janus kinase (JAK) inhibitor which can be used to treat conditions such as atopic eczema, rheumatoid arthritis, psoriatic arthritis, non-radiographic axial spondyloarthritis, ankylosing spondylitis, ulcerative colitis and crohn's disease.  

How should I take or use this medication?

• Swallow whole. Do not chew, break, or crush.
• This medication may be taken with or without food.
• You may take the medication with food if you have nausea/vomiting or stomach upset.
• This medication has to be taken regularly to obtain the full benefits of the medication. It may take weeks to months for an effect to be seen.

What should I do if I forget to take or use this medication?

Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose. Do not double the next dose to make up for the missed dose.

What precautions should I take when taking or using this medication?

Inform your healthcare professional if:

• You have severe infections (e.g., tuberculosis, shingles, fungal or bacterial or viral infections) or have immune system problems
• You have stomach problems or intestinal disease
• You have kidney problems
• You have liver problems
• You have lung problems
• You have personal or family history of heart problems, high blood pressure, stroke and/or blood clots
• You have any personal or family history of cancer
• You are pregnant or planning to become pregnant
• You are breast-feeding
• You are a current or past smoker
• You have any allergies

IMPORTANT:

The following severe side effects have been reported in some patients taking this medication:

If you experience these side effects, you should stop your medication and see your healthcare professional. 

Blood tests and other tests will be done before and while on this medication to decide if it is suitable for you, as well as to monitor for side effects.

What are some common side effects of this medication? ​

If any of the following side effects persist or are severe, you should consult your doctor.

• Symptoms of a common cold (blocked nose, runny nose, sneezing, sore throat, coughing, mild fever (below 38°C)
• Acne
• Headache
• Blister like rashes, including shingles
  • See a doctor immediately.
  • Consider discussing with your doctor the option of receiving an inactivated vaccine to help prevent shingles.
• Nausea, stomach upset
• Increase in cholesterol levels 

What are some rare but serious side-effects that I need to seek medical advice immediately? 

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

What food or medication should I avoid when I take or use this medication?

• Inform your doctor if you are taking any other medications, over-the-counter medications, including vitamin and mineral supplements, and herbal products.
• Consult your doctor or pharmacist before immunizations (vaccinations) as this medication may either raise the chance of an infection or reduce the effectiveness of the vaccine.
• Avoid crowded places and consumption of raw or under-cooked food (e.g., half-boiled eggs) while on this medication as it may reduce the ability of your body to fight against infection.

How should I store this medication?

Store in a cool and dry place, away from direct sunlight. Keep this medication away from children.

How do I throw away this medication safely? ​

Pack this medication into a black trash bag and seal it tightly before throwing it into the rubbish chute or bin.