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Afatinib
TS-ONE
- Article last reviewed 21 January 2026
- 12 mins read
What is this medication for?
This medication is also known as Tegafur-Oteracil-Gimeracil Capsules.
TS-ONE is usually used to treat stomach cancer and pancreas cancer.
How should I take or use this medication?
- Take TS-ONE two times a day, after food. Take the exact number of capsules and follow the dosing schedule instructed by your doctor.
- Swallow the tablet/capsule whole.
- Do not open, chew or crush the capsule.
- Inform your doctor or pharmacist if you have difficulty swallowing.
- Special handling of the medication is needed.
- Try not to touch the medication with your bare hands. Use the medication cup provided. Wash your hands after handling the medication.
What should I do if I forget to take or use this medication?
- If you forget to take a dose, skip the missed dose, and take it at the next scheduled time. Do not take two doses to make up for the missed dose.
- If you vomit out a dose of TS-ONE, do not take another dose to make up for it. Take your next dose at the usual time.
What precautions should I take when taking or using this medication?
- Inform your healthcare professional if:
- You are allergic to this medication or any of the other ingredients of this medication.
- You are taking any other medications (e.g. warfarin, phenytoin), including supplements, traditional medications and herbal remedies.
- You have any other medical conditions.
- You are going to receive any vaccination or surgery, including dental surgery.
- You have any plans to start a family in the future.
- TS-ONE may have an anti-fertility effect, which could be irreversible. You should discuss fertility preservation options with your doctor before starting treatment.
- You should not breastfeed during treatment.
- You should not become pregnant during treatment. You should use an effective birth control method during treatment and for at least 6 months after stopping TS-ONE.
- If you have a partner who could become pregnant, you should use an effective birth control method during treatment and for at least 6 months after stopping TS-ONE.
What are some common side effects of this medication?
The table below will list some of the common side effects as well as the rare but serious side effects.
| Side Effect | Management |
|---|---|
| Decrease in white blood cell count. This may increase your chances of getting an infection.. |
|
| Decrease in platelet count. Low platelet levels can increase your chance of bleeding. |
|
| Diarrhoea (loose and frequent stools) |
|
| Nausea or vomiting |
|
Mouth ulcers or sores.
|
|
| Hyperpigmentation |
|
| Heart problems |
|
| Liver problems | Proceed to the A&E department immediately if you experience any:
|
Symptoms of drug allergy including one or more of the following:
|
|
It is normal to experience some side effects from TS-ONE. As discussed with your doctor, taking TS-ONE will help your condition. Do not stop taking TS-ONE without checking with your doctor.
What food or medication should I avoid when I take or use this medication?
Avoid eating any raw, uncooked or under-cooked food as your immunity is weakened.
How should I store this medication?
Store in a cool and dry place, away from direct sunlight. Keep this medication away from children.
How do I throw away this medication safely?
Pack the medication into a bag and bring it back to the pharmacy where you received the medication from.
What else should I know about this medication?
Tips to help manage your condition while you are on TS-ONE
| Exercise | Light exercise is recommended as it helps to improve mobility, balance, and even emotional well-being. Avoid strenuous exercise, and rest when you are feeling tired. |
| Adequate hydration | Have plenty of hydration with 2 to 3 litres of fluids per day unless you have been informed by your doctor to limit how much fluids you can drink. This will decrease your chances of getting constipation and prevent dehydration. |
| Medical and dental treatment | If you need to go into hospital for any reason other than cancer, always inform the doctors and nurses that you are receiving anti-cancer treatment. Talk to your cancer doctor if you think you need dental treatment. Always inform your dentist that you are receiving anti-cancer treatment. |
| Seek support if you feel overwhelmed | It is normal to feel fearful or worried about your condition. Do not be afraid to share your concerns with your healthcare team or loved ones. There may be resources and support available to help you. |
Disclaimer
Please take note that the above is not a complete list of all possible side-effects. If you have any concerns about your medication or if you have other side-effects that you think are caused by this medication, please consult your doctor or pharmacist. If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.
This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (NHG Health, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.
Contributed By
- Pharmaceutical Society of Singapore