Rupatadine
- Article last reviewed 30 December 2025
- 7 mins read
What is this medication for?
Rupatadine belongs to a group of medicines known as antihistamines. It can be used for the relief of:
- Runny nose (due to a cold, flu or allergies)
- Itch in the eyes, nose or skin (due to an insect bite or allergies)
- Redness and swelling of skin and eyes
You can also find out about this medication by watching these videos:
They are available in English, 中文, Melayu and தமிழ்: Antihistamine (oral)
How should I take or use this medication?
- You may take this medication with or without food
- Take the medication when necessary to relieve your symptoms
- Do not exceed the maximum dose as recommended by your healthcare professional
What should I do if I forget to take or use this medication?
- As the medicine is to be taken only on a “as-needed” basis, there is no need to take the medication if you are not experiencing any symptoms.
- If it is prescribed to be taken regularly for certain conditions (e.g., chronic itching), it is important to follow the instructions stated on the medicine label given to you.
- If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue normally. Do not take two doses or extra medication to make up for the missed dose.
What precautions should I take when taking or using this medication?
Inform your healthcare professional if:
- You are allergic to this medication or any of the other ingredients of this medication
- You are pregnant, planning to become pregnant, or breastfeeding
- You are taking any other medications, including supplements, traditional medications and herbal remedies
- You have
- Liver or kidney problems
- Heart or abnormal heart rhythm problems
What are some common side effects of this medication?
- Affect alertness (drowsiness and fatigue)
- Avoid driving, operating machinery or other activities which require concentration while on this medication
- Note: Rupatadine is a newer antihistamine that is less likely to cause drowsiness
- Headache
- Dry mouth, skin and eyes
- Sip water regularly or suck an ice cube to help with mouth dryness
- Use lubricant eye drops to resolve eye dryness
What are some rare but serious side-effects that I need to seek medical advice immediately?
The symptoms of a drug allergy include one or more of the following:
- Swollen face/eyes/lips/tongue
- Difficulty in breathing Itchy skin rashes over your whole body
You can also find out about drug allergies by watching these videos:
They are available in English, 中文, Melayu and தமிழ்: Drug Allergies
Rarely this medication may cause:
- Fast, slow, or abnormal heartbeat
- Muscle pain or weakness
If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.
If you continue to experience symptoms for more than 2 weeks even with self-treatment or have any of the following symptoms:
- Blood in your phlegm or mucus
- Unexplained weight loss, constant fatigue, night sweats
Your condition may be too serious for self-treatment and you should consult a doctor.
What food or medication should I avoid when I take or use this medication?
- Avoid taking grapefruit or grapefruit juice as they may interact with this medication and increase the risk of side-effects
- Taking this medication with alcohol may worsen the drowsy side effect. Avoid alcohol while on this medication.
- Some medications may interact with Rupatadine and affect its effectiveness or increase the risk of side-effects. However, these medications may also be important for your treatment. Inform your healthcare professional of the other medications you are currently taking. Examples include:
- Medications for bacterial infections (e.g. clarithromycin, erythromycin)
- Medications for fungal infections (e.g. itraconazole, ketoconazole)
- Many over-the-counter medications contain antihistamines, always check with your healthcare professional before taking two over-the-counter medications at the same time to prevent overdosing.
How should I store this medication?
Store in a cool and dry place, away from direct sunlight. Keep this medication away from children.
How do I throw away this medication safely?
Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin.
Disclaimer
Please take note that the above is not a complete list of all possible side-effects. If you have any concerns about your medication or if you have other side-effects that you think are caused by this medication, please consult your doctor or pharmacist. If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.
This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (NHG Health, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.
Contributed By
- Pharmaceutical Society of Singapore
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