Nicotine Replacement Therapy – Nicotine Lozenge (Nicotinell®)
- Article last reviewed 30 June 2025
- 6 mins read
What is this medication for?
Nicotine Replacement Therapy (NRT) delivers nicotine without the other harmful chemicals present in cigarette smoke. It reduces the withdrawal symptoms experienced when you are trying to quit smoking, allowing you to focus on the other aspects in your effort to quit smoking
Nicotinell® Lozenge dissolves in the mouth to release a dose of nicotine to reduce your urge to smoke.
You can also find out about this medication by watching these videos:
They are available in English, 中文, Melayu and தமிழ்: Nicotine Replacement Therapy - Lozenge
How should I take or use this medication?
When you feel the urge to smoke, suck one lozenge to release a peppery taste then park the lozenge between your cheek and gum. Resume sucking the lozenge when the taste has faded. Repeat for about 30 minutes until the lozenge completely dissolves. You can suck on one lozenge every 1-2 hours.
Do not chew or swallow the lozenge.
Do not use more than the recommended maximum number of lozenges as instructed by your healthcare professional or use more than one lozenge each time.
What precautions should I take when taking or using this medication?
You should stop smoking once you start to use NRT. Smoking and using NRT at the same time may increase the risk of adverse effects from the additive effects of nicotine in your body.
If you continue to feel the urge to smoke or experience severe nicotine withdrawal symptoms even after using the NRT lozenges, please inform your healthcare professional as you may need other types of NRT.
Inform your healthcare professional if:
- You are pregnant, planning to become pregnant, or breastfeeding.
- You recently had a heart attack or stroke.
- You have active peptic ulcer disease.
- You have any other medical conditions.
- You are taking any other medications, including supplements, traditional medications and herbal remedies.
- You are less than 18 years old.
What are some common side effects of this medication?
- Throat irritation
- Jaw ache
- Increased salivation
- Hiccups
- Dry mouth
- Flatulence
- Stomach discomfort
- Heartburn
- Nausea and vomiting
- Dizziness
- Headache
These side effects usually occur as a result of intense sucking of lozenges. Suck the lozenge slowly and take longer breaks in between lozenges to reduce these side effects.
What are some rare but serious side-effects that I need to seek medical advice immediately?
The symptoms of a drug allergy include one or more of the following:
- Swollen face/eyes/lips/tongue
- Difficulty in breathing
- Itchy skin rashes over your whole body
If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.
You can also find out about drug allergies by watching these videos:
They are available in English, 中文, Melayu and தமிழ்: Drug Allergies
What food or medication should I avoid when I take or use this medication?
- Avoid coffee, tea, juices, acidic and fizzy drinks 15 minutes before and during use of nicotine lozenge as this may reduce nicotine absorption.
- Nicotine may reduce the effect of certain medications. When NRT dose is reduced or stopped, adjustments to these medications may be necessary.
- These medications include:
- Benzodiazepines (e.g. diazepam, lorazepam)
- Insulin
- Beta-blocker (e.g. bisoprolol, atenolol)
- Opioid painkillers (e.g. codeine)
- Inform your doctor or pharmacist about other medications – including over-the-counter medications, supplements and traditional/herbal remedies – that you are currently taking as they may affect the way you benefit from NRT.
How should I store this medication?
Store in a cool and dry place, away from direct sunlight. Keep this medication away from children.
How do I throw away this medication safely?
Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin.
Disclaimer
Please take note that the above is not a complete list of all possible side-effects. If you have any concerns about your medication or if you have other side-effects that you think are caused by this medication, please consult your doctor or pharmacist. If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.
This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (NHG Health, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.
Contributed By
- Pharmaceutical Society of Singapore