What is this medication for?
Letrozole is used to treat breast cancer that is hormone-sensitive. It may be used alone or in combination with other medications.
It works by reducing the amount of estrogen (a hormone) in your body, to slow down or stop the growth of breast cancer cells that need estrogen to grow.
How should I take or use this medication?
- Take Letrozole once a day, with or without food.
- Swallow the tablet/capsule whole.
- Do not break, chew or crush the tablet.
- Inform your doctor or pharmacist if you have difficulty swallowing.
What should I do if I forget to take or use this medication?
- If you forget to take a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take it at the next scheduled time. Do not take two doses to make up for the missed dose.
- If you vomit out a dose of Letrozole, do not take another dose to make up for it. Take your next dose at the usual time.
What precautions should I take when taking or using this medication?
- Inform your healthcare professional if:
- You are allergic to this medication or any of the other ingredients of this medication.
- You are taking any other medications, including supplements, traditional medications and herbal remedies.
- You have any other medical conditions such as heart, liver or kidney conditions.
- You should not breastfeed during treatment and for at least 3 weeks after stopping Letrozole.
- You should not become pregnant during treatment. You should use an effective birth control method during treatment and for at least 3 weeks after stopping Letrozole.
What are some common side effects of this medication?
The table below will list some of the common side effects as well as the rare but serious side effects.
| Side Effect | Management |
| Hot flushes (sudden sweating and feeling of warmth) |
|
| Vaginal itching, dryness, discomfort, (bleeding) or vaginal discharge |
|
| Muscle aches and/or joint pain |
|
| Feeling tired or lack of energy |
|
| Increase in cholesterol or triglycerides levels |
|
| Bone loss or thinning, which may lead to an increased risk of bone fractures |
|
Symptoms of drug allergy including one or more of the following:
| If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately. |
It is normal to experience some side effects from Letrozole. As discussed with your doctor, taking Letrozole will be beneficial for your condition. Do not stop taking Letrozole without checking with your doctor.
What food or medication should I avoid when I take or use this medication?
Avoid taking letrozole with tamoxifen, other anti-estrogen medications, or any medications containing estrogen (such as hormone replacement therapy), as these may make Letrozole less effective.
How should I store this medication?
Store in a cool and dry place, away from direct sunlight. Keep this medication away from children.
How do I throw away this medication safely?
Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin.
Disclaimer
Please take note that the above is not a complete list of all possible side-effects. If you have any concerns about your medication or if you have other side-effects that you think are caused by this medication, please consult your doctor or pharmacist. If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.
This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (NHG Health, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.
Contributed By
- Pharmaceutical Society of Singapore