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Erlotinib

Erlotinib is used to treat non-small cell lung and pancreatic cancer
  • Article last reviewed 30 August 2025
  • 12 mins read

What is this medication for?

Erlotinib is used to treat non-small cell lung and pancreatic cancer.

How should I take or use this medication?

  • Take Erlotinib:
    • Once daily at the same time each day.
    • Take on an empty stomach, either one hour before or two hours after eating
  • Swallow the tablet/capsule whole.
    • Do not break, chew or crush the tablet.
    • Inform your doctor or pharmacist if you have difficulty swallowing.

What should I do if I forget to take or use this medication?

  • If you forget to take a dose, take it as soon as you can if it is within 12 hours of the missed dose. If more than 12 hours have passed since the missed dose, skip the missed dose and take it at the next scheduled time. Do not take two doses to make up for the missed dose.
  • If you vomit out a dose of Erlotinib, do not take another dose to make up for it. Take your next dose at the usual time.

What precautions should I take when taking or using this medication?

  • Inform your healthcare professional if:
    • You are allergic to this medication or any of the other ingredients of this medication.
    • You are taking any other medications, including supplements, traditional medications and herbal remedies.
    • You have any other medical conditions.
    • You are going to receive any vaccination or surgery, including dental surgery.
    • You have any plans to start a family in the future.
      • Erlotinib may have an anti-fertility effect, which could be irreversible. You should discuss fertility preservation options with your doctor before starting treatment.
  • You should not breastfeed during treatment and for at least 2 weeks after stopping Erlotinib.
  • You should not become pregnant during treatment. You should use an effective birth control method during treatment and for at least 2 weeks after stopping Erlotinib.
  • If you have a partner who could become pregnant, you should use an effective birth control method during treatment and for at least 2 weeks after stopping Erlotinib.

What are some common side effects of this medication? ​

The table below will list some of the common side effects as well as the rare but serious side effects.

Side EffectManagement
Nausea or vomiting
  • Take small and frequent meals.
  • Avoid foods / smells that may make you feel nauseous, such as oily, fried or strong-smelling food.
  • Avoid tight-fitting clothes around the waist.
  • Your doctor may prescribe medications to help relieve or prevent nausea or vomiting. Take these as instructed.

Diarrhoea (loose and frequent stools)

 

  • Drink plenty of clear fluids (at least 2 litres or 8 cups every day).
  • Eat food that is gentler on the stomach such as porridge or soup.
  • Avoid milk, dairy products, high-fibre food and oily or spicy food.
  • Your doctor may prescribe medications to help relieve diarrhoea. Take these as instructed.
  • Proceed to the A&E Department immediately if you have very bad diarrhoea (for example increase in bowel movement of more than 4 times per day) that does not improve even after taking anti-diarrhoeal medications.

Mouth ulcers or sores. 

  • This can occur on the tongue, the sides of the mouth or in the throat and can lead to an infection.
  • Rinse your mouth regularly with an alcohol-free mouthwash or salt water to help reduce the chances of infection.
  • Brush your teeth gently after eating and at bedtime with a soft bristle toothbrush.
  • Rinse and brush your dentures after eating and soak them in denture solution overnight.
  • Avoid spicy food and take soft foods e.g. porridge.
  • Your doctor may prescribe medications to help relieve or prevent the mouth sores. Use these as instructed.
  • Inform your doctor if you are eating or drinking a lot lesser because of mouth pain.
Eye dryness causing discomfort, redness and increased production of tears
  • Your doctor may prescribe eye drops or gels to help moisturize and lubricate the eyes to relieve discomfort.
  • Inform your doctor if you experience eye pain, changes in vision and/or sensitivity to light or other changes
Feeling tired or lack of energy
  • Do not drive or operate machinery if you are feeling tired.
  • Eat well and get enough sleep. Prioritize tasks to ensure you make the best use of your energy.
  • Simple exercise such as walking can help to boost your energy.
  • Avoid alcohol as this may cause you to feel more tired and drowsy.

Acne-like rashes (pimples) may appear on the face, upper chest and back.

 

It usually develops within the first 2 weeks of treatment and will get better after stopping treatment.

 

Your skin may also become flaky and scaly.

  • Avoid direct sunlight during and 2 months after treatment. Apply sunscreen with an SPF (Sun Protection Factor) of at least 30. Also, you may wear a hat, long sleeves, and long pants outside on sunny days.
  • Apply moisturisers to dry areas.
  • You may be prescribed antibiotic cream or oral antibiotics to treat the rashes.
  • Inform your doctor if the acne-like rash becomes widespread and is bothering you.

 

 

 

 

                                             

Liver problems

Proceed to the A&E department immediately if you experience any:

  • Dark of tea-coloured urine
  • Pale or light-coloured stools
  • Yellowing of skin or eyes
  • Nausea, vomiting with loss of appetite
  • Severe abdominal pain
Lung problems

Proceed to the A&E department immediately if you have any new or worsening symptoms of lung problems such as shortness of breath, cough or chest pain.

Symptoms of drug allergy including one or more of the following:

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing

Itchy skin rashes over your whole body

  • If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

 

It is normal to experience some side effects from Erlotinib. As discussed with your doctor, taking Erlotinib will be beneficial for your condition. Do not stop taking Erlotinib without checking with your doctor.

What food or medication should I avoid when I take or use this medication?

Avoid taking certain fruits such as grapefruit, pomelo, starfruit and pomegranate when you are taking this medication. This is because these fruits may may affect how the body processes the drug and increase the risk of side-effects.

How should I store this medication?

Store in a cool and dry place, away from direct sunlight. Keep this medication away from children.

How do I throw away this medication safely? ​

For general waste: Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin. 

What else should I know about this medication? 

Tips to help manage your condition while you are on Erlotinib

ExerciseLight exercise is recommended as it helps to improve mobility, balance, and even emotional well-being. Avoid strenuous exercise, and rest when you are feeling tired.
Adequate hydrationHave plenty of hydration with 2 to 3 litres of fluids per day unless you have been informed by your doctor to limit how much fluids you can drink. This will decrease your chances of getting constipation and prevent dehydration.
Medical and dental treatment

If you need to go into hospital for any reason other than cancer, always inform the doctors and nurses that you are receiving anti-cancer treatment.

Talk to your cancer doctor if you think you need dental treatment. Always inform your dentist that you are receiving anti-cancer treatment.

Seek support if you feel overwhelmed

It is normal to feel fearful or worried about your condition.

Do not be afraid to share   your concerns with your healthcare team or loved ones.

There may be resources and support available to help you.

Disclaimer

Please take note that the above is not a complete list of all possible side-effects. If you have any concerns about your medication or if you have other side-effects that you think are caused by this medication, please consult your doctor or pharmacist. If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.

This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (NHG Health, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.