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Betamethasone, Clotrimazole, Gentamicin cream

Combiderm cream is used to treat infection caused by fungus and bacteria, and to reduce swelling (inflammation), redness and/or itch caused by infections. Learn how to use the medication, its common side effects, special precautions to watch out for, and more.
  • Article last reviewed 19 January 2026
  • 6 mins read

What is this medication for?

This medication is also known by other brand names such as Combiderm or Triderm cream. This cream contains a steroid, anti-fungal agent, and an antibiotic. It is used to treat the infection by the fungi and bacteria, and to reduce swelling (inflammation), redness and/or itch caused by infections.

How should I take or use this medication?

  • Use this medication as recommended by your healthcare professional. Consult your healthcare professional if you are not sure how to use this medication correctly.
  • Apply directly to the affected areas of the skin. Follow the instructions on your medicine label for information on how often you should apply the cream.
  • Apply a thin layer to the affected area and stop using when there are no more symptoms. Applying too much topical steroids may increase the risk of getting side effects, while using too little may decrease the effectiveness of the medication.
  • Do not bandage or cover the area after applying the medicine unless directed by the doctor. Occlusive dressing (airtight covering) may increase the amount of steroid absorbed through the skin and increase the risk of side effects.
  • One fingertip unit (FTU) is the amount of cream or ointment, squeezed out of a tube (with a standard 5 mm nozzle), from the tip of an adult’s index finger to the first crease of that finger. The image below shows what is meant by 1 FTU.
  • One FTU (about 0.5 grams) is enough to treat an area of skin two times the size of the adult’s hand. You may use this as a guide to decide the correct amount of cream or ointment to apply on the affected area.

 

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What should I do if I forget to take or use this medication?

If you forget to use the medication, apply the missed dose as soon as you remember. If it is almost time for your next application, only apply the usual amount. Do not double the amount of cream or apply extra medication to make up for the missed application.

What precautions should I take when taking or using this medication?

Inform your healthcare professional if:

  • You are allergic to these medications or any of the other ingredients of these medications

Do not use these medications for long periods of time unless instructed by your doctor. Follow your doctor’s instructions for how long to use it for.

What are some common side effects of this medication? ​

Side effects, such as thinning of the skin, reddish stretch marks and acne can occur if too much topical steroids are used incorrectly for a long period of time.

What are some rare but serious side-effects that I need to seek medical advice immediately? 

  • Pain, swelling or skin condition gets worse after using the medication

The symptoms of a drug allergy include one or more of the following: 

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

What food or medication should I avoid when I take or use this medication?

There are no specific foods or medications you need to avoid when using this medication.

How should I store this medication?

Store in a cool and dry place, away from direct sunlight. Keep this medication away from children. 

How do I throw away this medication safely? ​

Pack the medication into a bag and bring it back to the pharmacy where you received the medication from.

Disclaimer

Please take note that the above is not a complete list of all possible side-effects. If you have any concerns about your medication or if you have other side-effects that you think are caused by this medication, please consult your doctor or pharmacist. If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.

This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (NHG Health, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.