Medication Information Leaflet
Cabozantinib is used to treat kidney, liver and thyroid cancers that have spread to other parts of the body.
Cabozantinib comes in two brands: Cabometyx® and Cometriq®. Do not switch between brands as they are not interchangeable.
Take Cabozantinib once a day
Cabozantinib should be taken on an empty stomach (one hour before or two hours after a meal)
Do not break or crush the tablet. Swallow the tablet whole.
If you forget to take a dose, take it as soon as you remember. However, if it is less than 12 hours to your next dose, skip the missed dose and take your next dose at the usual time. Do not take two doses at the same time.
Inform your healthcare professional if:
You are allergic to this medication
You or your partner becomes pregnant or is planning for pregnancy
You are breastfeeding
You have any other medical conditions such as heart problems or high blood pressure
You are taking or intend to take any other medications, including supplements, traditional medications and herbal remedies
You have any recent or upcoming surgery
You have any dental problems
Practice good oral hygiene while you are taking Cabozantinib
Be sure to let your dentist know you are taking Cabozantinib so that appropriate precautions can be taken
Nausea, decreased appetite
Palms of the hands or soles of the feet may become numb, sore, red or dry
Moisturize these areas daily
Avoid wearing tight-fitting shoes
Feeling tired and lack of energy
Rinse your mouth after meals using an alcohol-free mouthwash or salt water
Brush your teeth with a soft toothbrush
Increased blood pressure
Symptoms of a drug allergy including one or more of the following:
Difficulty in breathing
Itchy skin rashes over your whole body
Very bad stomach pain
Signs of infection - fever of 38° C and above, chills, cough, sore throat, pain or burning feeling on passing urine
Unusual bleeding, bruising, black sticky stools or blood in the urine
Unusual weakness, tiredness or light-headedness
Signs of blood clot e.g. warmth, pain or redness with swelling on arm or leg
Chest pain or shortness of breath
Very bad diarrhea
Painful blisters and peeling of hands or feet
If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.
Avoid taking grapefruit or grapefruit juice when you are taking this medication as it may interact with your medication and increase the risk of side-effects.
Store in a cool and dry place, away from direct sunlight. Keep this medication away from children.
This article was last reviewed on
Wednesday, November 22, 2023
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