Cabozantinib is used to treat kidney, liver and thyroid cancers that have spread to other parts of the body.
Cabozantinib comes in two brands: Cabometyx® and Cometriq®. Do not switch between brands as they are not interchangeable.
How should I take or use this medication?
Take Cabozantinib once a day
Cabozantinib should be taken on an empty stomach (one hour before or two hours after a meal)
Do not break or crush the tablet. Swallow the tablet whole.
Inform your doctor or pharmacist if you have difficulty swallowing
What should I do if I forget to take or use this medication?
If you forget to take a dose, take it as soon as you remember. However, if it is less than 12 hours to your next dose, skip the missed dose and take your next dose at the usual time. Do not take two doses at the same time.
What precautions should I take when taking or using this medication?
Inform your healthcare professional if:
You are allergic to this medication
You or your partner becomes pregnant or is planning for pregnancy
You should use effective birth control during and for four months after stopping treatment
You are breastfeeding
Do not breastfeed during and for four months after stopping treatment
You have any other medical conditions such as heart problems or high blood pressure
You are taking or intend to take any other medications, including supplements, traditional medications and herbal remedies
You have any recent or upcoming surgery
You have any dental problems
Practice good oral hygiene while you are taking Cabozantinib
Be sure to let your dentist know you are taking Cabozantinib so that appropriate precautions can be taken
What are some common side effects of this medication?
Nausea, decreased appetite
Take small, frequent meals throughout the day
Diarrhea
Drink plenty of clear fluids to replace those lost (two litres everyday)
Palms of the hands or soles of the feet may become numb, sore, red or dry
Moisturize these areas daily
Avoid wearing tight-fitting shoes
Feeling tired and lack of energy
Do not drive or operate machinery when you feel tired
Mouth sores
Rinse your mouth after meals using an alcohol-free mouthwash or salt water
Brush your teeth with a soft toothbrush
Increased blood pressure
Monitor your blood pressure regularly and record it down. Inform your doctor if you notice an increasing trend.
What are some rare but serious side-effects that I need to seek medical advice immediately?
Symptoms of a drug allergy including one or more of the following:
Swollen face/eyes/lips/tongue
Difficulty in breathing
Itchy skin rashes over your whole body
Very bad stomach pain
Signs of infection - fever of 38° C and above, chills, cough, sore throat, pain or burning feeling on passing urine
Unusual bleeding, bruising, black sticky stools or blood in the urine
Unusual weakness, tiredness or light-headedness
Signs of blood clot e.g. warmth, pain or redness with swelling on arm or leg
Chest pain or shortness of breath
Very bad diarrhea
Painful blisters and peeling of hands or feet
If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.
What food or medication should I avoid when I take or use this medication?
Avoid taking grapefruit or grapefruit juice when you are taking this medication as it may interact with your medication and increase the risk of side-effects.
How should I store this medication?
Store in a cool and dry place, away from direct sunlight. Keep this medication away from children.
How do I throw away this medication safely?
Pack Cabozantinib into a bag and bring it back to the pharmacy where you received it from.
Disclaimer
If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.
This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (National Healthcare Group, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.
Last updated on August 2020
This article was last reviewed on
Saturday, April 30, 2022