Pyridoxine is also known as Vitamin B6. It is essential for various processes in the body, such as protein metabolism and formation of haemoglobin. Learn how to use the medication, its common side effects, special precautions to watch out for, and more.

What is this medication for?

Pyridoxine is also known as Vitamin B6. It is essential for various processes in the body, such as protein metabolism and formation of haemoglobin.

Pyridoxine on its own or in combination with other Vitamin B (e.g. B1, B2, B3 & B6) is used to treat or prevent Vitamin B6 deficiency in certain groups of people like:

• People on anti-tuberculosis medication, isoniazid 
• People with idiopathic sideroblastic anaemia (red blood cells do not form properly)
• People with autoimmune disorders e.g. rheumatoid arthritis, inflammatory bowel disease
• Premenstrual syndrome

Pyridoxine is also available in various combinations (e.g. B1, B6 & B12) to help manage symptoms of nerve problems such as numbness or tingling in the hands or feet.

How should I take or use this medication?

Pyridoxine is available in tablet form.

• Take this medication as prescribed by your healthcare professional
• Do not stop taking your medication without checking with your healthcare professional.
• You may take this medication with or without food. 
• This medication should usually be taken in the morning, as they may help with energy levels. If it is taken at night or close to bedtime, it might cause wakefulness or alertness.
• Do not take other pyridoxine-containing products while on this medication to prevent overdose.

What should I do if I forget to take or use this medication?

If you forget to take a dose, take it as soon as you remember. Then take your next dose at the usual time. Do not take two doses to make up for the missed dose.

What precautions should I take when taking or using this medication?

Inform your healthcare professional if: 

• You are allergic to this medication or any of the other ingredients of this medication.
• You are taking any other medications, including supplements, traditional medications and herbal remedies.

What are some common side effects of this medication?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Inform your healthcare professional if you have any side effects that bother you or do not go away, such as

• Headache
• Nausea
  • May take after meals if you experience nausea

What are some rare but serious side-effects that I need to seek medical advice immediately?

The symptoms of a drug allergy include one or more of the following: 

• Swollen face/eyes/lips/tongue
• Difficulty in breathing
• Itchy skin rashes over your whole body

Excessive intake of pyridoxine may lead to peripheral neuropathy (a nerve disorder). The symptoms of peripheral neuropathy include tingling, burning or numbness in the hands or feet.

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

How should I store this medication?

Store in a cool and dry place, away from direct sunlight. Keep this medication away from children. 

How do I throw away this medication safely?

Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin. 

Disclaimer

Please take note that the above is not a complete list of all possible side effects. If you have any concerns about your medication or if you have other side effects that you think are caused by this medication, please consult your doctor or pharmacist.

If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.

This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (National Healthcare Group, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.

Last updated on June 2025