Medication Information Leaflet

What is this medication for?

Inclisiran is a small piece of RNA that is absorbed by the liver to increase the liver’s ability to remove bad cholesterol. This lowers the amount of ‘bad cholesterol’ in the blood.

High ‘bad cholesterol’ levels can cause blood vessels to clog up and this may lead to chest pain (angina), heart attack or stroke. By reducing the amount of bad cholesterol in the body, this medication reduces the risk of future heart attack and stroke.

This medication may also be used for patients with high ‘bad cholesterol’ levels in their blood because of a hereditary condition (a medical condition that runs in the family).

How should I take/use this medication?

  • This medication should be administered at the scheduled times as advised by your physician. If there are any issues sticking to the prescribed regimen, please seek the advice of a healthcare professional.
  • This injection is only to be administered by a healthcare professional. It will be injected into the skin of your tummy (abdomen) or the skin of your upper arm or thigh.

What should I do if I forget to take/use this medication?

If you miss your appointment to have your Inclisiran administered, contact your healthcare provider as soon as you remember so that you can arrange your next treatment within three months of the scheduled date. Otherwise, you will need to start your schedule again.

What precautions should I take?

Inform your healthcare professional if:

  • You are allergic to this medication or any of the other ingredients of this medication
  • You are pregnant, planning to become pregnant, or breastfeeding
  • You have liver problems
  • You have kidney problems, or are receiving dialysis
  • You are taking any other medications, including supplements, traditional medications and herbal remedies.

What are some common side-effects of this medication?

  • Injection-site reactions – redness, pain or swelling where the injection is administered

What are some rare but serious side-effects that I need to seek medical advice immediately?

The symptoms of a drug allergy include one or more of the following:

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately

How should I store this medication?

You may be asked to collect Inclisiran injections from your pharmacy and to store them until your scheduled appointments.

Store in a cool and dry place, away from direct sunlight. Keep this medication away from children.

How should I throw away this medication safely?

As your healthcare provider will be administering the injection for you, he/she will handle the disposal of the medication.



Please take note that the above is not a complete list of all possible side effects. If you have any concerns about your medication or if you have other side effects that you think are caused by this medication, please consult your doctor or pharmacist.

If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.

This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (National Healthcare Group, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.

Last updated on Jun 2023

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