Copyright © Ministry of Health Singapore. All Rights Reserved.
Medication Information Leaflet
The following leaflet addresses the use of higher doses of amoxicillin and co-amoxiclav/amoxicillin-clavulanate in children when treating their infections.
Both Amoxicillin and Co-amoxiclav/ Amoxicillin-Clavulanate contain amoxicillin as the active ingredient. Amoxicillin belongs to a group of antibiotics known as penicillin, and is used to treat a wide range of infections caused by bacteria, including infections of the chest (pneumonia), middle ear (otitis media), sinuses (sinusitis), tonsils (tonsillitis), urinary tract, and skin and soft tissue.
High-dose amoxicillin (such as 80 to 90mg/kg/day) is usually prescribed to overcome the antibiotic resistance that has developed to the common bacteria that may cause these infections such as the following:
Ear (otitis media), and/or
Amoxicillin or Co-amoxiclav/Amoxicillin-Clavulanate is usually taken two or three times a day.
You may take this medication after food to reduce stomach discomfort.
If you forget to take a dose, take it as soon as you remember. Then take your next dose at the usual time. Do not take two doses to make up for the missed dose.
Inform your healthcare professional if:
You are allergic to this medication or any of the other ingredients of this medication.
You are taking any other medications, including supplements, traditional medications and herbal remedies.
Some common side effects that you may experience include
Nausea and upset stomach
The symptoms of a drug allergy include one or more of the following:
Difficulty in breathing
Itchy skin rashes over your whole body
Very rarely, this medication may cause severe watery and/or bloody diarrhea, fever and painful stomach cramps. This can happen one to two days after you start taking an antibiotic, up to several weeks after you finish taking the antibiotic. This is due to overgrowth of the bacterium, C. difficile, in the colon.
If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.
Take probiotics at least 2 hours apart from antibiotics as the antibiotics may reduce the effectiveness of probiotics.
Depending on whether you are taking the tablet or the suspension; the storage conditions may differ. Ask your healthcare professionals about the proper storage conditions of the antibiotic you are taking.
This article was last reviewed on
Thursday, May 20, 2021