Methotrexate is an immunosuppressive drug which helps to control over-activity of the immune system by interfering with some actively growing cells within the body.
Folic/folinic acid can be prescribed to reduce this side effect.
Nausea, vomiting, diarrhoea or loss of appetite
Take medication after food to minimise the side effects. Folic/folinic acid can be prescribed to reduce this side effect. Alternatively, Methotrexate can be converted to an injection form. Consult your doctor immediately if you see bloody vomit or stools.
Slow loss of hair
It is generally reversible when the medicine is discontinued.
These usually resolve readily upon decreasing the dose or stopping the medicine.
(Warning signs: Persistent coughing, breathlessness or chest pain)
Consult your doctor immediately. It is advisable to stop smoking.
(Warning signs: Yellowing of eye whites or skin, dark or tea-coloured urine, or constant abdominal pain)
Consult your doctor immediately. Avoid alcohol. Inform your doctor if you have any liver disease (e.g. jaundice, hepatitis) or if any of your family members has hepatitis.
(Warning signs: May be asymptomatic; unusual bleeding or bruising, lip or mouth ulcers with ‘flu-like’ symptoms may occur)
Consult your doctor immediately. Monitoring the effects of your new treatment is important for early detection of side effects. For your safety, you need to do regular blood tests for monitoring.
Infections e.g. shingles, chickenpox
(Warning signs: Fever, chills, persistent severe sore throat or mouth ulcers)
Consult your doctor immediately.
If you develop rashes, facial swelling or shortness of breath after taking the medication, you could be allergic to the medication. Please seek medical attention immediately.
If you have any problem with your treatment, please contact your doctor, pharmacist or rheumatology nurse clinician.
Please keep all medications out of reach of children.
© Tan Tock Seng Hospital, Singapore 2017. All rights reserved. All information correct as of August 2017. No part of this document may be reproduced, copied, reverse compiled, adapted, distributed, commercially exploited, displayed or stored in a database, retrieval system or transmitted in any form without prior permission of Tan Tock Seng Hospital. All information and material found in this document are for purposes of information only and are not meant to substitute any advice provided by your own physician or other medical professionals.
This article was last reviewed on
Thursday, June 28, 2018
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