Medication Information Leaflet
Topical fluorouracil is used on the skin to treat skin cancer and skin conditions that could become cancerous. Fluorouracil interferes with the growth of abnormal cells which are eventually destroyed.
This medication is also used for other skin conditions as determined by your doctor.
Before you apply this medication to the skin, clean the affected area and dry well.
Wait for 10 minutes, then apply a small amount of medication to the affected skin.
The medication should be applied in a thin layer to the affected area and its surrounding (determined by the doctor) once or twice daily or as advised by your doctor.
The total area of skin treated at any one time should not be more than 23x23 cm (500 cm2) or 9x9 inches.
Do not cover the area with a bandage unless directed by your doctor.
If you miss a dose of this medication, apply it as soon as possible. However, if it is almost time for your next application, skip the missed application and carry on as before. Do not apply a double dose.
Be careful if you are applying the medication around your eyelids, nose and lips and avoid any contact with the eyes or mouth. Wash your hands thoroughly after use.
Do not apply the medication on open wounds.
If somebody else is helping you to apply the medication, they should take precautions to avoid the medication being absorbed through their skin. It is recommended that they should wear disposable surgical gloves, remove them after use and wash their hands thoroughly.
Inform your healthcare professional if:
You are allergic to this medication or any of the other ingredients of this medication.
You have any red/irritated/open sores on your skin.
You are pregnant, planning to become pregnant, or breastfeeding.
Certain side effects of this medication are not unusual and may even disappear during treatment. If any of the following effects persist or are severe, consult your doctor.
Redness, soreness, scaling and peeling of affected skin
Skin irritation, burning, pain and swelling at the site of application
Enlarged lymph nodes may appear transiently
This medication may make you more sensitive to the sun
Do check with your healthcare professional if you are taking any other medications or applying any other medications on the skin being treated.
Store in a cool and dry place, away from direct sunlight. Keep this medication away from children.
Pack the medication into a bag and bring it back to the pharmacy where you received the medication from.
If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.
This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (National Healthcare Group, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.
Last updated on March 2021
This article was last reviewed on
Wednesday, November 22, 2023
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