Medication Information Leaflet

What is this medication for?

Soliqua® is an injection that contains two medications: Insulin Glargine and Lixisenatide.


These medications help to control diabetes.


Insulin glargine is long-acting and helps to lower blood sugar throughout the day.


Lixisenatide works by slowing the movement of food from your stomach to the small intestine, hence slowing down absorption of sugars into the body. It also regulates the amount of insulin made by your body in a sugar-dependent manner. 


How should I take/use this medication?

  • Soliqua® is to be injected once a day
  • Soliqua® should be injected 1 hour before meal, preferably the same meal every day, with the most convenient meal
  • Inject Soliqua® into the fatty tissue that is between the skin and muscle layer on the upper arms, thighs or tummy (abdomen).
  • Use the injection technique advised by your doctor or nurse and as described in the manual.
  • Ensure that the liquid is clear and colourless before use.
  • Do not use it if it appears cloudy, grainy or if particles are seen. 

You may refer to this article for more details on insulin injection techniques.


What should I do if I forget to take/use this medication?

If you missed a dose, inject the next dose at the usual time the following day.


Do not inject two doses at the same time. 


What precautions should I take?

Inform your healthcare professional if you:

  • Are allergic to this medication or any of the ingredients in this medication
  • Are eating less than usual due to sickness or dietary changes as your dosage may need to be changed
  • Are travelling across different time zones. You might need to adjust the number of meals and the dose of your insulin based on where you travel to.
  • Are pregnant, planning to become pregnant or breastfeeding
  • Have stomach or intestinal problems or delayed stomach emptying (gastroparesis)
  • Have or have had problems with your pancreas or stones in your gallbladder
  • Have kidney or liver problems


What are some common side-effects of this medication?

Like all medications, this medication may cause some possible side effects but not everyone experiences them. Consult your healthcare professional if any of the side effects becomes severe and bothersome.


The common side effects of Glargine and Lixisenatide include:

  • Nausea
  • Vomiting
  • Diarrhoea
  • Stuffy or runny nose
  • Sore throat
  • Low blood sugar (hypoglycaemia)


This medication may cause low blood sugar (hypoglycemia). Symptoms of low blood sugar