Sodium Zirconium Cyclosilicate (Lokelma)

Lokelma is used to treat hyperkalaemia. Learn how to use the medication, its common side effects, special precautions to watch out for, and more.

What is this medication for?

This medication is used for the treatment of hyperkalaemia, a condition where there are excessive amounts of potassium in the body. This medication does so by reducing the absorption of potassium into the body and increasing its removal through the stools.

How should I take/use this medication?

  • Do not stop taking your medication without checking with your healthcare professional.
  • You may take this medication with or without food.
  • Empty the entire contents of the sachet(s) into a drinking glass containing approximately 45 ml of water.
  • Stir well and drink while the powder, which does not dissolve, is still suspended. The suspension is tasteless and will appear as a cloudy liquid.
  • If the powder settles, the water should be stirred again. Ensure all of the product is taken.
  • If needed, rinse the glass with a small amount of drinking water and drink immediately; repeat until no powder remains.

What should I do if I forget to take/use this medication?

If a patient misses a dose they should be instructed to take the next usual dose at their normal time.

What precautions should I take?

Inform your healthcare professional if:

  • You are allergic to this medication or any of the other ingredients of this medication
  • You are pregnant or planning to become pregnant
  • You are breastfeeding, although this medication is not expected to be present in breast milk
  • You notice swelling of your legs or arms
  • You are going to have an abdominal X-ray done

What are some common side-effects of this medication?

  • Swelling of your legs or arms due to build up of fluid
    • May require starting or increasing your dose of diuretics, a type of medication to remove water from the body
  • Constipation, diarrhea, abdominal pain/bloatedness, nausea, and vomiting
    • May resolve as you continue the medication
  • Feeling tired or having muscle weakness or cramps.
    • This may be a sign that your blood potassium has become too low. You should inform your doctor immediately if these symptoms become severe or persistent.

What are some rare but serious side-effects that I need to seek medical advice immediately?

The symptoms of a drug allergy include one or more of the following:

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately

What food or medication should I avoid when I take this medication?

This medication can transiently reduce stomach acidity, it should be administered at least 2 hours before or 2 hours after oral medications that rely on stomach acidity for absorption. Consult your healthcare professionals for further advice on the suitability of this medication with your other medications

How should I store this medication?

Store in a cool and dry place, away from direct sunlight. Keep this medication away from children.

How should I throw away this medication safely?

Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin.



Please take note that the above is not a complete list of all possible side effects. If you have any concerns about your medication or if you have other side effects that you think are caused by this medication, please consult your doctor or pharmacist.

If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.

This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (National Healthcare Group, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.

Last updated on April 2024

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