Medication Information Leaflet

What is this medication for?

Repaglinide is used in the treatment of diabetes. It works together with lifestyle changes, such as having a healthy diet and regular exercise, to reduce blood sugar levels. It helps the pancreas to release more insulin to bring your blood sugar levels down.

How should I take/use this medication?

You can take this medication 30 minutes before your meals. Do not skip or delay meals after taking the medication.

What should I do if I forget to take/use this medication?

If you missed a dose, skip the dose you missed. 

Do not double your dose or use extra medication to make up for the missed dose. Take your next dose 30 minutes before your next meal. 

What precautions should I take?

Inform your healthcare professional if you:
  • Are allergic to this medication or any of the other ingredients of this medication
  • Are pregnant, planning to become pregnant or breastfeeding
  • Have heart, kidney or liver problems
  • Drink alcohol often
  • Are eating less than usual due to sickness as your medication dosage may need to be changed
  • Are exercising more than usual or making changes to your usual diet as your blood sugar levels may be affected

If your doctor has informed you that you need to do a fasting blood test, skip your medication until after you have your blood taken and are ready to eat.

What are some common side effects of this medication?

Like all medications, this medication may cause some possible side effects but not everyone experiences them. Consult your healthcare professional if any of the side effects becomes severe and bothersome.

The common side effects of Repaglinide include:
  • Low blood sugar (hypoglycemia) – management of low blood sugar is mentioned below
  • Headache
  • Joint or back pain
  • Blocked or runny nose
  • Diarrhoea

Symptoms of low blood sugar include:
  • Weakness
  • Dizziness
  • Hunger
  • Sweating
  • Trembling
  • Blurred vision
  • Walking unsteadily
  • Fast heartbeat
If you experience any of these low blood sugar symptoms, do the following immediately: 
    Step 1: Check your blood sugar level with a home blood sugar meter (glucometer) if available. If your blood sugar level is less than 4 mmol/L, take 15 grams of fast-acting sugar. Examples of 15 grams of fast-acting sugar include:
    • 3 glucose tablets or 
    • Half a glass of fruit juice (200ml) or
    • Half a can of soft drink or sweetened drink (175ml) or
    • 1 can of less sugar soft drink (330ml) or
    • 3 teaspoons of sugar, honey or syrup

    Step 2: Monitor yourself for 15 minutes. If you have a glucometer (home blood sugar meter), check your blood sugar level again after 15 minutes. 

    Step 3: If your blood sugar level is still less than 4 mmol/L or you still have symptoms of low blood sugar, you should take another 15 grams of fast-acting sugar as per Step 1.

    If your symptoms do not go away, see a doctor or go to the hospital immediately.

    Step 4: Take your meal or snack if your blood sugar level is 4 mmol/L and above after consuming the fast-acting sugar earlier on. 

What are some rare but serious side effects that I need to seek medical advice immediately?

The symptoms of a drug allergy include one or more of the following:
  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body
If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

See a doctor or go to the hospital immediately if your blood sugar level is always low (less than 4 mmol/L) or you continue to experience symptoms of low blood sugar even after taking some sugar (see instructions above for management of low blood sugar). 

What food or medication should I avoid when I take/use this medication?

Avoid taking alcohol with this medication as this may increase your risk of having low blood sugar.

How should I store this medication?

Store in a cool and dry place, away from direct sunlight. Keep this medication away from children.

How should I throw away this medication safely?

Pack this medication into a black trash bag and seal it tightly before throwing it into the rubbish chute or bin.

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Please take note that the above is not a complete list of all possible side effects. If you have any concerns about your medication or if you have other side effects that you think are caused by this medication, please consult your doctor or pharmacist.

If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.

This article is jointly developed by members of the National Medication Information workgroup, and supported by the Ministry of Health. The workgroup consists of cluster partners (National Healthcare Group, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.

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Last updated on May 2023

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