Medication Information Leaflet
Prochlorperazine is a type of anti-emetic agent which blocks dopamine (a type of chemical messenger). By blocking dopamine, signals are unable to travel to the vomiting center in the brain, therefore relieving the sensation of nausea (feeling sick) and vomiting on its own or nausea and vomiting due to other causes such as Meniere disease or inner ear problems for example vertigo (giddiness).
It is available as tablet and injection formulation
Follow the instructions on the medication label and take this medication as prescribed by your doctor
If your symptoms become persistent or worsening, seek help from your medical doctor as soon as possible
You may take this medication with or without food.
If you forget to take a dose, take it as soon as you remember. Then take your next dose at the usual time. Do not take two doses to make up for the missed dose.
Do not take double the dose for any missed dose iIf you are taking this medication as and when needed.
Inform your healthcare professional if:
You are allergic to this medication or any of the other ingredients of this medication
You are pregnant, planning to become pregnant, or breastfeeding
You are taking any other medications, including supplements, traditional medications and herbal remedies
Medical conditions such as heart disease, dementia, liver and kidney disease, seizure (fits), phaeochromocytoma (tumour on the adrenal gland)
The symptoms of a drug allergy include one or more of the following:
Difficulty in breathing
Itchy skin rashes over your whole body
Rarely this medication may cause:
High fever, severe muscle stiffness, confusion, irregular blood pressure (signs and symptoms of neuroleptic malignant syndrome)
Muscle stiffness and spasms (such as in the face, neck and back), difficulty in speaking or swallowing, twitching or upward rolling of eyes (dystonia)
Uncontrollable movements (such as in the face, tongue, jaw or other parts of the body) (tardive dyskinesia)
Fever, sore throat and/or mouth ulcers that do not go away (symptoms of blood dyscrasia)
Increased prolactin hormone in the blood (hyperprolactinemia)
Changes in menstrual cycle in females (irregular or stopping of menstrual periods) and/or
Abnormal breast swelling, soreness or secretion (in both men and women)
If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately
Avoid drinking alcohol while taking this medication as it can increase drowsiness side effect
Store in a cool and dry place, away from direct sunlight. Keep this medication away from children.
Pack this medication into a black trash bag and seal it tightly before throwing it into the rubbish chute or bin.
If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.
This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (National Healthcare Group, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.
Last updated on Jul 2022
This article was last reviewed on
Friday, September 15, 2023
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