Medication Information Leaflet
Paliperidone belongs to a class of medications known as atypical (second-generation) antipsychotics. It is used to treat and prevent the return of symptoms in Schizophrenia and other mental health related conditions such as:
Hearing, seeing or sensing things that are not real
Having mistaken beliefs
Being overly suspicious
Paliperidone may be used for other conditions. Check with your healthcare professional if you are unsure why you are given this medication.
For Paliperidone ER Tablet:
Follow the directions on your medication label and take the medication as prescribed by your doctor.
Paliperidone may be taken with or without food. Swallow the tablets whole. Do not break, cut, crush or chew the tablet. You may notice the tablet shell in the stools sometimes. This is because our body is unable to dissolve the empty tablet shell after the medicine has been absorbed by the body.
This medication needs to be taken regularly for a few weeks before you feel its full benefits. You should not stop taking this medication even if you do not feel better at the beginning. Continue to take this medication even after you feel better to prevent your symptoms from returning.
Do check with your doctor on how long you will have to be on this medication.
Do not stop taking your medication without checking with your healthcare professional.
For Paliperidone depot injection:
If you forget to take a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose. Then take the next dose at your usual timing. Do not take two doses to make up for the missed dose.
Please call up your doctor to arrange for an appointment visit.
Inform your healthcare professional if:
You are allergic to this medication or any of the other ingredients of this medication
You are pregnant, planning to become pregnant, or breastfeeding. If you are pregnant and/or breastfeeding, your doctor would have discussed the potential benefits and side effects with you and should you have further questions or concerns, do consult your doctor.
You are taking any other medications including over-the-counter medications, supplements, traditional Chinese medicine and herbal remedies. Some of them may affect how this medication works or cause serious drug interactions.
You have diabetes. Paliperidone may sometimes worsen blood sugar control in diabetes. Maintain regular check-ups with your doctor.
You have or have ever had:
Other drug allergies
Medical conditions such as:
Kidney disease, serious pre-existing stomach or intestinal narrowing or other related disorders, difficulty swallowing, irregular heartbeat or other heart problems, breast cancer, stroke
High or low blood pressure, high cholesterol/ fats in the blood, seizures (fits), Alzheimer’s disease (a type of dementia), Parkinson’s disease
The mentioned side effects generally affect up to 10% of patients.
Most of the side effects listed here will improve with time. Speak to your doctor if they persist, get worse or are affecting your daily life.
The symptoms of a drug allergy include one or more of the following:
Difficulty in breathing
Itchy skin rashes over your whole body
Rarely this medication may cause:
Confusion, high fever, severe muscle stiffness, irregular blood pressure (signs and symptoms of neuroleptic malignant syndrome)
Uncontrollable movements (such as in the face, tongue, jaw or other parts of the body) (tardive dyskinesia)
Sudden weakness or numbness in the face, arms or legs, and speech or vision problems
Excessive hunger, unusual increase in thirst or passing large amount of urine (symptoms of high blood sugar)
If you experience any of these side effects, you should stop your medication and inform your healthcare professional immediately.
Please also take note that the above listed side effects are not exhaustive. If you have any concerns about your medication or if you have other side effects that you think are caused by this medication, please consult your doctor or pharmacist.
Avoid drinking alcohol while taking Paliperidone as it can cause excessive drowsiness.
Store in a cool and dry place, away from direct sunlight. Keep this medication away from children.
Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin.
If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.
This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (National Healthcare Group, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.
Last updated on Jun 2021
This article was last reviewed on
Wednesday, November 22, 2023
In partnership with