Obinutuzumab is used to treat certain types of blood cancers. Learn how to use the medication, its common side effects, special precautions to watch out for, and more.
It is used to treat certain types of blood cancers, namely Chronic Lymphocytic Leukaemia (CLL) and Follicular Lymphoma (FL). The medication works by targeting the CD20 protein that is found on the surface of the cancer cells. By binding to the CD20 protein, this helps the immune system to recognize and kill the cancer cells.
This medication may also be used for other indications as determined by your doctor.
Obinutuzumab is injected into the vein as an infusion, which usually takes several hours.
The first few infusions will take longer as the nurse will start the infusion at a slower rate, and increase the speed if you do not have any infusion reaction.
It is normal to experience some side effects from Obinutuzumab, which are usually mild.
The table below will list some of the common side effects as well as the rare but serious side effects.
Side Effect | Management |
Infusion-related reaction
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Decrease in white blood cell count. This may increase your chances of getting an infection.
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Decrease in platelet count. Low platelet levels can increase your chance of bleeding.
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Tumour lysis syndrome (TLS) may occur, which is a condition caused by cancer cells breaking down too quickly and releasing their contents into the blood. When there are too much minerals and waste products released from the dying cells, this may cause an imbalance of the minerals in your body and this may lead to organ damage. TLS is a serious condition and needs to be treated as soon as possible. |
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Hepatitis B reactivation Some people may have been infected by the Hepatitis B virus before – a virus which affects the liver. Treatment with Obinutuzumab may cause the infection to return and cause more liver damage. |
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Problems with normal brain function, which may include symptoms such as:
These could be symptoms of a rare but serious infection of the brain called Progressive Multifocal Leukoencephalopathy. |
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Avoid eating any raw, uncooked or under-cooked food as your immunity is weakened.
Tips to help manage your condition while you are on Obinutuzumab
Exercise | Light exercise is recommended as it helps to improve mobility, balance, and even emotional well-being. Avoid strenuous exercise, and rest when you are feeling tired. |
Adequate hydration | Maintain adequate hydration with 2 to 3 litres of fluids per day unless you have been informed by your doctor to restrict fluids. This will decrease your chances of getting constipation and prevent dehydration. |
Medical and dental treatment | If you need to go to the hospital for any reason other than cancer, always inform the doctors and nurses that you are receiving anti-cancer treatment. Talk to your cancer doctor if you think you need dental treatment. Always inform your dentist that you are receiving anti-cancer treatment. |
Seek support if you feel overwhelmed | It is normal to feel fearful or worried about your condition. Do not be afraid to talk about your concerns with your healthcare team or loved ones. There may be resources and support available to help you. |
Please take note that the above is not a complete list of all possible side effects. If you have any concerns about your medication or if you have other side effects that you think are caused by this medication, please consult your doctor or pharmacist.
If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.
This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (National Healthcare Group, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.
Last updated on Apr 2025
This article was last reviewed on Friday, April 25, 2025