Medication Information Leaflet
It is used to treat idiopathic pulmonary fibrosis and other chronic fibrosing interstitial lung diseases (conditions that cause reduced lung function and chronic shortness of breath due to excessive scarring and hardening of lung tissue).
The medication works by reducing fibrosis (thickening and scarring of lung tissue) in the lungs, hence delaying the progression of the disease and improving symptoms of breathlessness.
Do not stop taking your medication without checking with your healthcare professional.
This medicine should be taken with or after food.
Swallow capsules whole with liquid. Do not open, chew, or crush the capsules.
If you forget to take a dose, skip that dose and take your next dose at the usual time. Do not take two doses to make up for the missed dose.
Inform your healthcare professional if:
You are allergic to this medication or any of the other ingredients of this medication.
You are pregnant, planning to become pregnant, or breastfeeding.
Nintedanib is associated with potential harm, birth defects, or death to an unborn baby. Women who may become pregnant should take a pregnancy test before starting treatment and should use highly effective birth control at the start of treatment, during treatment, and for at least 3 months after the last dose.
You are taking any other medications, including supplements, traditional medications and herbal remedies.
You have liver or heart disease, history of blood clots, bleeding problem or a family history of a bleeding problem, or had recent surgery in your abdominal area.
You are a smoker, and currently smoking.
You are planning to donate blood. Do not donate blood for at least 3 months after stopping the medication. This is to prevent passing donated blood to a pregnant woman and causing harm to the baby.
Diarrhoea, nausea and vomiting, reduced appetite
Take the medication after a meal to reduce gastric discomfort and nausea
Diarrhoea usually occurs within the first 3 months of treatment. Drink more water when having diarrhoea
Giddiness, feeling tired, headache
Do not drive or operate machinery if you feel giddy or tired
Upper respiratory tract infection
The symptoms of a drug allergy include one or more of the following:
Difficulty in breathing
Itchy skin rashes over your whole body
Some of other rare but serious side effects include:
Liver problem: Signs include dark urine or light coloured stools, nausea, vomiting, loss of appetite, stomach pain, yellowing of your eyes or skin
Heart attack: Symptoms include chest pain or pressure, pain in your arms, back, neck, or jaw, or shortness of breath
Stroke: Symptoms include numbness or weakness on one side of your body, trouble talking, headache, or dizziness
Bleeding problems such as unusual bleeding, bruising, wounds that do not heal
Tear in your abdominal wall (perforation): Pain or swelling in abdominal area, may or may not be accompanied with chills, fever, nausea or vomiting.
Leakage of protein in your urine (proteinuria): Symptoms include frothy urine, leg swelling, weight gain
If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.
Consult your healthcare professional if you are currently taking any other medications e.g. for epilepsy (seizures) or antibiotics for Tuberculosis treatment, as some of these medications may reduce the effectiveness of Nintedanib.
Store in a cool and dry place, away from direct sunlight. Keep this medication away from children.
For general waste: Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin.
If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.
This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (National Healthcare Group, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.
Last updated on Oct 2022
This article was last reviewed on
Wednesday, November 22, 2023
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