Fexofenadine is used to relieve or prevent symptoms of hives, hay fever, itch, runny nose and other types of allergies. Learn how to use the medication, side effects, special precautions, and more.

What is this medication for?

Fexofenadine is used to relieve or prevent symptoms of hives, hay fever, itch, runny nose and other types of allergies.
It is a second-generation antihistamine that works by blocking the effects of histamine, a substance released by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes. 

Fexofenadine is available in the form of tablets or as a suspension. The medication may be available for certain indications without a prescription under the supervision of a pharmacist; or may be prescribed by a health care professional. 

How should I take/use this medication?

Fexofenadine may also be prescribed on an “as needed” basis (e.g., runny nose). You may take the medication when necessary to relieve your symptoms. Do not exceed the maximum dose as stated on the medicine label given to you. 
It may also be prescribed regularly for certain conditions (e.g., chronic itching). It is important to follow the instructions stated on the medicine label given to you.

For Fexofenadine suspension, shake the bottle well before each use.

What should I do if I forget to take/use this medication?

If you are taking this medicine regularly and you miss a dose, take it as soon as you remember. Then take your next dose at the usual time. Do not take two doses to make up for the missed dose.

If you are taking it only on a “as-needed” basis; there is no need to take the medication if you are not experiencing any symptoms.

What precautions should I take?

Inform your healthcare professional if: 

  • You are allergic to this medication or any of the other ingredients of this medication.
  • You are pregnant, planning to become pregnant, or breastfeeding.
  • You are taking any other medications, including supplements, traditional medications, and herbal remedies. 

What are some common side-effects of this medication?

Fexofenadine is generally well tolerated. 
Compared to first-generation antihistamines such as Chlorpheniramine; Fexofenadine is less likely to cause drowsiness. 

Some common side effects include:

  • Stomach disturbances such as  
    • Diarrhoea
    • Vomiting
      • You may consume smaller but more frequent meals, and avoid spicy, fatty food, to reduce the risk of vomiting. 
  • Dizziness 
  • Headache

What are some rare but serious side-effects that I need to seek medical advice immediately?

The symptoms of a drug allergy include one or more of the following: 

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

What food or medication should I avoid when I take this medication?

Separate administration of Fexofenadine with aluminium or magnesium containing antacids by at least 2 hours. Antacids are a group of medicines that help relieve  heartburn, gastric reflux, and indigestion. Consuming Fexofenadine together with antacids may reduce the absorption of Fexofenadine.

Do not take grapefruit, orange, or apple juice together with this medication as fruit juices may reduce the amount of Fexofenadine in your body. Separate fruit juices with the medication for at least 4 hours.

High fat meals may reduce the amount of Fexofenadine in your body as well.

Inform your healthcare professional if you are taking any other medicines, including over-the-counter medications. Many over-the-counter medications contain antihistamines, always check with your health care professional before taking two over-the-counter medications at the same time to prevent overdosing.

How should I store this medication?

Store in a cool and dry place, away from direct sunlight. Keep away from children. 

For Fexofenadine suspension, throw away any remaining suspension after 60 days of opening. 

How should I throw away this medication safely?

Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin.



Please take note that the above is not a complete list of all possible side effects. If you have any concerns about your medication or if you have other side effects that you think are caused by this medication, please consult your doctor or pharmacist.

If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.

This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (National Healthcare Group, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.

Last updated on April 2024

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