Medication Information Leaflet
Entacapone is used together with medication containing Levodopa (either Levodopa/carbidopa or Levodopa/benserazide) to treat Parkinson’s disease.
Parkinson’s disease is a progressive disorder of the nervous system that affects movement. Entacapone works by increasing the effectiveness of Levodopa to help improve muscle control and allows more normal body movements.
Entacapone is taken together with medication containing Levodopa
You may take this medication with or without food
Do not stop taking Entacapone without checking with your healthcare professional.
When you stop this medication, you may have signs of withdrawal. If you need to stop
this medication, follow how to stop it as your doctor has told you. Seek medical advice
immediately if you have any of these signs when lowering the dose or stopping this
medication: fever, confusion, severe muscle stiffness, not caring about things, anxiety,
depression, feeling tired, trouble sleeping, sweating, or pain.
If you forget to take a dose, take it as soon as you remember. Then take your next dose at the usual time. Do not take two doses to make up for the missed dose.
Inform your healthcare professional if:
You are allergic to this medication or any of the other ingredients of this medication
You have glaucoma (high eye pressure), heart, liver, kidney or mental health condition
You have phaechromocytoma (a tumour of the adrenal gland which is found on top of the kidneys)
You are pregnant, planning to become pregnant, or breastfeeding
You are taking any other medications, including supplements, traditional medications and herbal remedies.
Nausea or vomiting
Reddish brown discoloration of urine
Involuntary movements of the body
The symptoms of a drug allergy include one or more of the following:
Difficulty in breathing
Itchy skin rashes over your whole body
Some rare but serious side effects includes
Strong urge that are hard to control (such as eating, gambling, spending money)
Hallucinations (seeing or hearing things that are not there)
Breakdown of muscles
If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.
Iron supplements (e.g. ferrous gluconate, ferrous sulphate, iron polymaltose) may affect the absorption of Entacapone. Space iron 2 hours apart from Entacapone.
Certain medications used for treatment of depression (e.g. Desipramine, Venlafaxine, Paroxetine, Moclobemide) may interact with Entacapone. Discuss with your healthcare professional regarding alternative medication.
Store in a cool and dry place, away from direct sunlight. Keep this medication away from children.
Pack this medication into a black trash bag and seal it tightly before throwing it into the rubbish chute or bin.
Please take note that the above is not a complete list of all possible side effects. If you have any concerns about your medication or if you have other side effects that you think are caused by this medication, please consult your doctor or pharmacist.
If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.
This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (National Healthcare Group, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.
Last updated on Mar 2023
This article was last reviewed on
Wednesday, November 22, 2023
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