Medication Information Leaflet

What is this medication for?

Daratumumab is commonly used for the treatment of multiple myeloma. It works by targeting a specific protein on the myeloma cells so your immune system can recognize, attack and kill the myeloma cells.

How should I take/use this medication?

You will receive this medication either into the veins or under the skin.

What should I do if I forget to take/use this medication?

You should inform your doctor immediately.

What precautions should I take?

Inform your healthcare professional if:

  • You are allergic to this medication or any of the other ingredients of this medication
  • You are pregnant or planning to get pregnant
    • Taking this medication while you are pregnant may harm the unborn baby. Females who are able to become pregnant should use an effective birth control to prevent pregnancy during treatment and for at least 3 months after your last dose of Daratumumab
  • You are breastfeeding or plan to breastfeed. Do not breastfeed while you are on this medication
  • You are taking any other medications, including supplements, traditional medications, and herbal products.

What are some common side-effects of this medication?

  • Temporary decrease in blood counts
    • This may put you at higher risk of infections, bleeding or bruising and feeling tired
    • Reduce your risk of getting an infection by:
      • Maintaining good hand hygiene. Wash your hands often during the day especially before you eat or after using the toilet.
      • Avoiding crowds and staying away from people who are sick. Wear a mask if necessary.
      • Eating freshly cooked food. Avoid raw meats, vegetables, eggs, half-cooked or uncooked food
    • Brush your teeth gently with a soft bristle toothbrush to prevent gum bleeding
    • Be careful when handling sharp objects such as scissors or knives
  • Loose and frequent stools (diarrhoea)
    • When you are having diarrhoea, reduce intake of foods high in fibre, such as raw fruits and vegetables which may cause softer and more frequent stools
    • Maintain your nutrition by eating easily digestible foods, such as soups, and ensure you are drinking sufficient fluid (at least 2 litres a day)
    • Avoid spicy and/or fried food, alcohol, coffee, tea, milk and dairy products
    • Take antidiarrheal medicine as instructed to manage your diarrhoea. Inform your doctor if the antidiarrhoeal medicine does not help with your diarrhoea
  • Hard stools (constipation)
    • Increase intake of foods high in fibre, such as fruits and vegetables, and ensure you are drinking sufficient fluid
    • Increasing daily exercise may also help to improve constipation
  • Feeling tired
    • Take short naps or breaks throughout the day
    • Do simple exercises, such as walking to boost your energy
  • Muscle/joint pain
    • Painkillers may be prescribed by your doctor to help with the pain
  • Administration-related reactions may occur within 48 hours of having Daratumumab
    • You will be prescribed medications before and after the infusion to prevent a reaction
    • Symptoms may include fever, chills, chest pain, fast heartbeat, rash, cough, throat tightness or irritation, runny or stuffy nose, facial swelling or difficulty breathing
    • Inform your nurse immediately if this happens while you are receiving Daratumumab

What are some rare but serious side-effects that I need to seek medical advice immediately?

The symptoms of a drug allergy include one or more of the following:

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

Other serious side effects include:

  • Infections
    • Signs of an infection include:
      • Fever (temperature over 38°C)
      • Chills
      • Severe sore throat
      • Cough with thick or green phlegm
      • Cloudy or foul smelling urine
      • Painful, tender or swollen red skin, wounds or sores
  • Unusual bleeding
    • Signs of unusual bleeding include
      • Bruising without a cause or bruising that gets bigger
      • Dark (black or red), sticky stools
      • Coughing out blood
      • Vomit that looks like coffee grounds
      • Blood in the urine
      • Bleeding that you cannot stop

If you experience any of these symptoms, you should stop your medication and see your doctor immediately

What food or medication should I avoid when I take this medication?

Not applicable

How should I store this medication?

Store in the refrigerator between 2oC to 8oC. Do not freeze. Keep this medication away from children.

How should I throw away this medication safely?

This medication will usually be administered by nurses and be discarded by healthcare professionals after use.


Please take note that the above is not a complete list of all possible side effects. If you have any concerns about your medication or if you have other side effects that you think are caused by this medication, please consult your doctor or pharmacist.

If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.

This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (National Healthcare Group, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.

Last updated on Aug 2023

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