Medication Information Leaflet
Biosimilars are the non-branded versions of the original biologic. Original reference biologics are usually more expensive because of the high cost of researching and manufacturing them, therefore biosimilars can be marketed once the patent on the original biologic has expired.
Biosimilars are comparable in terms of quality, safety and efficacy to their version of an approved original biologics but are more affordable.
Both biologics and biosimilars are one kind of disease-modifying anti-rheumatic drugs (also known as “DMARDs”). They reduce uncontrolled immune processes and inflammation in your joints, skin, muscles and gut. This improves symptoms, reduces flares, stops disease progression and improves quality of life.
The term “biologic” or “biosimilar” simply means the medications are derived from animal or human proteins and not from chemicals (unlike other medications). They are highly effective medications that have been used for years.
Biologics target specific parts of the immune system. It can block actions of specific types of immune cells such as white blood cells called T-cell or B-cell. It can also block specific proteins in the immune system such as tumour necrosis factor-alpha (TNF-alpha), interleukin (IL) 17-A, IL-12, IL-23, IL-6, interferon and CD-20 (protein found on B-cell). These cells or proteins are known to be involved in the inflammation processes implicated in various medical conditions.
Common examples of biologics
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TNF-alpha blocker
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IL-1 blocker
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IL-6 blocker
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IL-17 blocker
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IL-23 blocker
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IL-12/23 blocker
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B-cell blocker
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T-cell blocker
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Integrin receptor blocker
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Adalimumab
Certolizumab
Etanercept
Golimumab
Infliximab
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Anakinra, Canakinumab Rilonacept | Tocilizumab | Ixekinumab Secukinumab | Guselkumab Risankizumab | Ustekinumab | Belimumab Rituximab | Abatacept | Vedolizumab |
They are indicated in a wide range of medical conditions such as:
Biologics and biosimilars are given by subcutaneous injection (injected into fat tissue under the skin) or intravenous infusion (injected directly into a vein) because these proteins can be damaged by stomach acid if given by mouth. Infusions will require administration by a healthcare professional in a hospital or clinic while self-injection can be performed by a patient or caregiver at home.
The injection may be given daily, weekly, every few weeks or every year. Your doctor will discuss with you which biologic or biosimilar is most appropriate for you, how to give and how often to be given.
Side effects for biologics and biosimilars
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Common > 10%
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Uncommon 1-3%
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Rare < 1 in 1000
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If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.
This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (National Healthcare Group, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.
Last updated on Oct 2022
This article was last reviewed on Friday, December 23, 2022