• The medication is usually taken once a day, preferably at the same time of the day.
• This medication should be taken with food or a milky drink.
• Check with your pharmacist or doctor for the correct dose if you weigh less than 40kg.
• Start one to two days before entering the area with malaria risk and continue to take the medication every day during the trip.  After leaving the area with malaria risk, continue to take the medication daily and for one week after travel or once you return to Singapore. It is important to complete the full course for complete protection. 
• If you find it difficult to swallow the tablets, you can crush or mix the medication with small amounts of water, milk or other beverages.
• Do not stop taking your medication before checking with your healthcare professional.
  

• You are allergic to Atovaquone, Proguanil hydrochloride or any of the other ingredients of this medication.
• You are pregnant or breast-feeding. Avoid pregnancy and use contraceptives while taking this medication and for 2 weeks after the last dose.
• You are taking any other medications, including supplements, traditional medications and herbal remedies.
• You have a history of kidney problems, liver problems, seizures (epilepsy or convulsions) or depression.
• You have tuberculosis.
  

What are some common side-effects of this medication?

• Severe skin reactions
• Skin rash, which may blister and looks like small targets (central dark spots, surrounded by paler area with a dark ring around the edge) (erythema multiforme).
• Severe widespread rash with blisters and peeling skin, particularly occurring around the mouth, nose, eyes and genitals (Stevens-Johnson syndrome).
• Liver problems
• Symptoms include dark urine or light coloured stools, nausea, vomiting, loss of appetite, stomach pain, yellowing of your eyes or skin.
• Anemia
• A condition where you do not have enough red blood cells.
• May present with worsening tiredness, rapid breathing, pale skin/lips/nails, fast heartbeat while resting. 
• Severe infection
• May present with high fever, severe chills, body aches, sore throat.
• Drug allergy (symptoms include one or more of the following)
  
• Swollen face/eyes/lips/tongue.
• Difficulty in breathing.
• Itchy skin rashes over your whole body.
  

• Tetracycline (antibiotic)
• Metoclopramide (medicine to treat nausea or vomiting)
• Rifampin or Rifabutin (antibiotic)
• Etoposide (used to treat cancer) 
• Efavirenz, Zidovudine, Indinavir (medicine to treat HIV)
• Warfarin, Dabigatran, Apixaban or Rivaroxaban (oral anticoagulants)
  

• Wearing long-sleeved clothing and long trousers between sunset and sunrise.
• Applying insect repellent containing more than 20% DEET (N-Diethyl-meta-toluamide) for adults or 10% and less DEET for children on exposed skin. DEET is a common active ingredient in mosquito repellents.
• Using mosquito coils in the room at night.
• Sleep with mosquito nets around your bed, with the net edges tucked under the bed or sleep in a screened room.
• Spray insecticide where mosquitos may rest. Mosquito larvae survive well in clear, slow-flowing streams.
• Avoid going to an area where malaria is common.