Medication Information Leaflet

What is this medication for?

Amiodarone is used in the treatment of abnormal heartbeat. It works by correcting the rhythm of your heartbeat and also by slowing your heartbeat if it is beating too fast.

How should I take/use this medication?

  • Do not stop taking your medication without checking with your healthcare professional.
  • You may take this medication with or without food.

What should I do if I forget to take/use this medication?

If you miss a dose, take the missed dose as soon as you remember. If it is almost time for your next dose, take only the usual dose. Do not double your dose or use extra medication to make up for the missed dose. 

What precautions should I take?

Inform your healthcare professional if: 
  • You are allergic to this medication, iodine or any of the other ingredients of this medication
  • You are pregnant, planning to become pregnant, or breastfeeding
  • You have problems with your thyroid gland
  • You are taking any other medications, including supplements, traditional medications and herbal remedies 

What are some common side-effects of this medication?

Some side effects of Amiodarone may include one or more of the following:
  • Thyroid problems:
    • More sensitive to heat or cold
    • Weight gain or loss
    • Feeling anxious more easily or feeling tired/ restless
  • Eye problems:
    • Change in vision (e.g. Blurred vision), eye pain
    • Do not drive or operate tools or heavy machinery if your vision is affected. Your doctor may also recommend an eyesight test to monitor for such side effects
  • Nerve problems:
    • Numbness, tingling or painful sensations of hands, legs or feet
  • Skin problems:
    • Blue-grey colouring on skin, and you may get sun-burnt more easily 
    • Avoid being in the sun unless needed. Use a sunblock, sunglasses or wear covered clothes to protect your skin and eyes from too much sunlight exposure
Inform your healthcare professional if any of these symptoms do not go away and are bothersome to you.

What are some rare but serious side-effects that I need to seek medical advice for immediately?

It is very important that you are on regular follow-up with your doctor to monitor for any possible side effects. Inform your healthcare professional if you have any of the following side effects.

Amiodarone may worsen existing abnormal heart rhythm, which may be dangerous. Symptoms of abnormal heart rhythm include one or more of the following: 
  • Irregular heartbeat e.g. slowed heartbeat or palpitations
  • Severe dizziness or fainting spells
Very rarely, Amiodarone may cause injury to the liver or the lungs. Symptoms of liver problems are dark urine, light-coloured stools, feeling very tired or sick, or yellowing of your skin or eyes. Symptoms of lung problems are breathlessness, cough that does not go away and fever. 

Lastly, the signs of a drug allergy include one or more of the following: 
  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body
If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

What food or medication should I avoid when I take this medication?

  • Avoid taking grapefruit and grapefruit juice when you are taking this medication as these may interact with your medication and increase the risk of side-effects.
  • If you intend to take any over-the-counter medications, supplements, herbal remedies or traditional medicine, consult your healthcare professional first to confirm that it is safe to take with Amiodarone.

How should I store this medication?

Store in a cool and dry place, away from direct sunlight. Keep this medication away from children. Throw away all expired medications. 

How should I throw away this medication safely?

Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin. 

If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.

This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (National Healthcare Group, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.

Last updated on July 2019

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