Administration Leaflet: Oral Administration of Vitamin K Ampoule

Medication Information Leaflet

​This leaflet explains the correct method of breaking and administering Vitamin K orally from the glass ampoules.

The glass ampoules are designed to ensure a clean break, provided the following steps are followed:

​Step 1: 
  • Shake the ampoule until all the solution is at the bottom of the ampoule.
  • The solution should be clear; do not use it if it looks cloudy. 
Step 2: 
  • Hold the bottom part of the ampoule between the thumb and first finger of one hand.
  • Ensure that the spot on the ampoule is facing towards you. 
Step 3: 
  • If possible, cover the top of the ampoule with a tissue or towel. Then hold the top of the ampoule between the thumb and first finger of your other hand.
​Step 4: 
  • Snap the top of the ampoule off by pushing away from the side with the spot.
​Step 5: 
  • Place the syringe (provided together with the ampoule) vertically into the ampoule.
  • Withdraw the solution into the syringe until it reaches the correct marking on the syringe.
  • Hold the syringe against the light to check whether the solution is clear and also ensure that no glass pieces are stuck to the tip of the dispenser.
  • If unsure, expel the solution into a small cup to check for any glass pieces – if the solution is clear, withdraw again from the cup into the syringe.
Step 6: 
  • Administer the contents of the syringe directly into the mouth.

How should I store this medication?

Store in a cool and dry place, away from direct sunlight. Keep this medication away from children. 

How should I throw away this medication safely?

Throw the glass ampoules into a metal tin or thick plastic container (e.g. detergent bottles).

If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.

This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (National Healthcare Group, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.

Last updated on May 2022

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