Tianeptine is an antidepressant and is used to treat symptoms of low mood.


​What is this medication used for​​

Tianeptine is an antidepressant and is used to treat symptoms of low mood such as:

  • feelings of sadness
  • feelings of hopelessness or worthlessness
  • feeling bad about yourself
  • suicidal thoughts
  • ​poor sleep, energy or appetite.

The medicine may be used for other conditions – check with your doctor.


Dosage and How to Use​​

Follow the directions on your medicine label and take the medicine exactly as directed. 

Tianeptine can be taken with or without food.

The medicine may not work for you straightaway. Continue to take it regularly. It may take a few weeks before you feel the full benefits of the medicine. 

Even after you feel better, continue to take this medicine regularly to prevent your symptoms from returning. Do check with your doctor on the appropriate length of treatment you need. 

Do not stop taking it or adjust the dose without talking to your doctor or pharmacist first. You may experience unpleasant effects if you suddenly stop taking the medicine.

Missed a​ Dose​​​   

Take the missed dose as soon as you remember it. However, if it is more than half way between the doses, skip the missed dose and take your medicine at the usual time. 

Do not take two doses at the same time to make up for a missed one. 

If you have problems remembering your doses, speak to your pharmacist or doctor.


Side Effects, Precautions, Contraindication​​​

Before using this medicine:​​

Tell your doctor if you have or have ever had cardiovascular disease; kidney disease; gastrointestinal disease; fructose, glucose, & galactose intolerance; drug allergies; undergoing an operation involving general anaesthesia; or if you have been taking other antidepressants in the past 2 weeks.  

FOR WOMEN: Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. 

Possible Side Effects ​​  

Like all medicines, tianeptine causes some POSSIBLE side effects but not everyone experiences them. 
Common side effectsWhat can I do about it?
(Generally affect up to 10% of patients)
Most of the side effects below improve as your body gets used to the medicine. Speak to your doctor or pharmacist if they persist, worsen or become too bothersome.
​Nausea​Take the medicine with or after food.

Take small but frequent meals; avoid rich or spicy foods.
Drowsiness, tiredness​
Avoid driving, or engaging in activities requiring concentration.
Dry mouth
Chew sugar-free gum
Suck on sugar-free hard candies
Sip water regularly
Drink more water, eat more high-fibre foods, and exercise regularly

Consult a doctor or pharmacist if you need a laxative
Get up slowly from sitting or lying down position.

Having more dreams or nightmares​
Speak with the doctor if any of these become bothersome.​

Check with your doctor as soon as possible if you experience any of the following: 

~ Allergic reaction: skin rash, itching, difficulty in breathing, swollen tongue, lips, eyes, or face.

~ Yellow skin or eyes, pain in your upper stomach, dark-coloured urine

~ Severe muscle ache

~ Fast, pounding or irregular heartbeat, chest pain

~ Blurred vision

~ Difficulty passing urine

If you have any concerns about your medicine or have other side effects that you think are caused by this medicine, please consult your doctor or pharmacist.

Precautions while using this medicine:​​​​

  • Avoid drinking alcohol while taking tianeptine as it can worsen symptoms of depression, increase anxiety, and cause excessive drowsiness.
  • Your mental condition may change in unexpected ways especially in the first few weeks of treatment and during dose changes. Contact your doctor immediately if you experience new or increasing thoughts of harming yourself, worsening anxiety, restlessness, violent behaviour, or other changes in mood and behaviour. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.
  • Taking some other medicines with tianeptine may cause problems. Be sure to tell all doctors, pharmacists, dentists and other health care providers who seeing you about all medicines and natural remedies you are taking. 

Handling and Storage

Store this medicine at room temperature, away from direct light, heat and moisture (not in the bathroom) and out of reach of children. 
Throw away any medicine that is expired or no longer needed. 

Do not share the medicine with other people.

If you have questions/concerns about this medicine, please ask your doctor or pharmacist.

Institute of Mental Health

Pharmacy Department​​
10 Buangkok View
Singapore 539747

For medication enquiries: (during office hours)

IMH Clinic B/ Sayang Wellness: 63892077

IMH Clinic C (NAMS): 63893666

Community Wellness Clinic, Queenstown: 64715797

Community Wellness Clinic, Geylang: 67461724

Child Guidance Clinic (HPB): 64353807

Child Guidance Clinic (Sunrise Wing): 63892410

Email: enquiry@imh.com.sg


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