Bupropion is an antidepressant used to treat symptoms of low mood.


​What is this medication used for 

Bupropion is an antidepressant used to treat symptoms of low mood such as:​
  • feelings of sadness
  • feelings of hopelessness or worthlessness
  • ​feeling bad about yourself
  • suicidal thoughts
  • poor sleep, energy or appetite.

​​Bupropion is also used as an aid to quit smoking. It may also be used for other conditions – check with your doctor.


Dosage and How to Use​ 

Follow the directions on your medicine label and take the medicine exactly as directed. 

Bupropion can be taken with or without food. Swallow the tablet whole. Do NOT break, split or crush the tablet.

If you have to take bupropion twice a day, take the first dose in the morning and the second dose at least 8 hours later, preferably in the late afternoon or early evening.

If you are taking bupropion for low mood:
Bupropion may not work for you straightaway. Continue to take it regularly. It may take a few weeks before you feel the full benefits of the medicine. Even if you feel better, continue to take bupropion regularly to prevent your symptoms from returning. Do check with your doctor on the appropriate length of treatment you need.

If you are taking bupropion to quit smoking:
Your doctor or pharmacist would have asked you to set a date to stop smoking (a "quit date"). Start taking bupropion as prescribed by your doctor 1 week before the quit date. A full course of treatment is usually 7 – 9 weeks. Let your doctor know if you are still smoking after 7 weeks of treatment.

Do not stop taking or adjust the dose without talking to your doctor or pharmacist first. You may experience unpleasant effects if you suddenly stop taking bupropion.​

Missed a Dose

Take the missed dose as soon as you remember it. However, if it is more than half way between the doses, skip the missed dose and take your medicine at the usual time. 

Do not take two or more doses at the same time to make up for a missed one.

If you have problems remembering your doses, speak to your pharmacist or doctor.


Side Effects, Precautions, Contraindication​​​ 

Before using this medicine:​​

Tell your doctor if you have any drug allergies or have ever had heart, liver, or kidney disease; seizures (fits); eating disorders; diabetes; urinary problems; eye problems; high cholesterol; high or low blood pressure; bipolar disorder; schizophrenia.

FOR WOMEN: Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. 

Possible Side Effects ​​​  

Like all medicines, bupropion causes some POSSIBLE side effects but not everyone experiences them. ​​

Common side effects
What can I do about it?​
(Generally affect up to 10% of patients)
Most of the side effects stated below improve as your body gets used to the medicin​e. Speak to your doctor or pharmacist if they persist, worsen or become too bothersome. ​​​
Nausea or vomiting​​
Take the medicine with or after food.

Take small but frequent meals; avoid rich or spicy foods.
Difficulty sleeping
Avoid daytime naps; listen to relaxing music at bedtime.

Avoid taking the last dose near bedtime.
Dry mouth​
Chew sugar-free gum or suck on sugar-free hard candies. Sip water regularly.
Drink more water, eat more high-fibre foods, and exercise regularly

Consult a doctor or pharmacist if you need a laxative
Mild nervousness​
May occur at the start of treatment and improves over time.
Headache; fast heartbeat; weigh​t loss​
Speak with the doctor if any of these become bothersome.​


Check with your doctor as soon as possible if you experience any of the following: 

~ Allergic reaction: skin rash, itching, difficulty in breathing, swollen tongue, lips, eyes, or face.

~ Swelling in hands, ankles or feet

~ Flu-like symptoms (fever, chills, sore throat); mouth sores / ulcers

~ Severe vomiting or diarrhoea, loss of appetite, abdominal pain 

~ Unexplained fever, confusion, fast heartbeat, severe weakness, uncontrolled movements or twitching of muscles

~ Feelings of intense agitation or anxiety, restlessness or inability to sit still, or irritability

~ Unusual thoughts; talking, feeling, and acting with excitement that you cannot control 

~ Seizures (fits)

~ Severe or continuing headache, or ringing in the ears

~ Fast, pounding or irregular heartbeat

If you have any concerns about your medicine or have other side effects that you think are caused by this medicine, please consult your doctor or pharmacist.​​​

Precautions while taking this medicine:

  • Avoid drinking alcohol while taking bupropion as it can worsen symptoms of depression, increase anxiety, and cause excessive drowsiness.
  • Your mental condition may change in unexpected ways especially in the first few weeks of treatment and during dose changes. Contact your doctor immediately if you experience new or increasing thoughts of harming yourself, worsening anxiety, ​restlessness, violent behaviour, or other changes in mood and behaviour. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.​
  • Taking some other medicines with bupropion may cause problems. Be sure to tell all doctors, pharmacists, dentists and other health care providers who seeing you about all medicines and natural remedies that you are taking.​

Handling and Storage 

Store this medicine at room temperature, away from direct light, heat and moisture (not in the bathroom) and out of reach of children. Throw away any medicine that is expired or no longer needed. 

Do not share the medicine with other people.

If you have questions/concerns about this medicine, please ask your doctor or pharmacist.

​Institute of Mental Health

Pharmacy Department​​
10 Buangkok View
Singapore 539747

For medication enquiries: (during office hours)

IMH Clinic B/ Sayang Wellness: 63892077

IMH Clinic C (NAMS): 63893666

Community Wellness Clinic, Queenstown: 64715797

Community Wellness Clinic, Geylang: 67461724

Child Guidance Clinic (HPB): 64353807

Child Guidance Clinic (Sunrise Wing): 63892410

Email: enquiry@imh.com.sg



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