Medication Information Leaflet
Domperidone is used to provide relief from nausea and vomiting.
It may also be used to provide relief from symptoms of indigestion, such as bloating, excessive fullness, stomach discomfort, excessive burping and heartburn after eating.
Domperidone works by blocking the action of a chemical messenger, dopamine, which helps to stop you from feeling sick (nausea) and prevents vomiting. It also works to increase movement of food through the stomach and intestines more easily, which helps to relieve the symptoms of bloating, fullness and indigestion.
Domperidone may also be used for other medical conditions, please check with your healthcare professional.
Oral tablets/oral syrup: Take half to one hour before food
Suppositories: Use this medication as instructed by your healthcare professional. It should only be inserted into the buttocks.
This medication is usually used for a short period of time, unless advised otherwise by your doctor.
If you forget to take a dose, take it as soon as you remember. Then take your next dose at the usual time. Do not take two doses to make up for the missed dose.
Inform your healthcare professional if:
You are allergic to this medication or any of the other ingredients of this medication
You are taking any other medications, including supplements, traditional medications and herbal remedies
You have an existing or a history of heart problems (especially rapid, slow or irregular heartbeats)
You are aged 60 years or older
You have kidney or liver disease
You have a tumour of the pituitary gland called prolactinoma
You have a stomach condition (e.g. bleeding or blockage in your gut) where an increase in gut contractions can harm you.
Suck ice chips or sugar free candy or drink frequent sips of water
Headache or migraine
You may take paracetamol
Drink sufficient water to replace the loss of fluids
Irritation to the buttocks area (with use of suppository)
Consult your healthcare professional if the symptoms do not go away or become bothersome.
The symptoms of a drug allergy include one or more of the following:
Difficulty in breathing
Itchy skin rashes over your whole body
Very rarely (affect less than 1% of patients):
Abnormal or rapid heartbeat
Uncontrolled movements of the eye, tongue or legs (signs and symptoms of an extrapyramidal side effects)
If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately
Certain antibiotics, antifungals, antivirals, heart medications, medications to treat mental or mood disorders may increase the risk of side effects when taken with domperidone.
Avoid taking grapefruit or grapefruit juice when you are taking this medicine as grapefruit may interact with domperidone and increase the risk of side effects.
Store in a cool and dry place, away from direct sunlight. Keep this medication away from children.
Pack this medication into a black trash bag and seal it tightly before throwing it into the rubbish chute or bin.
If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.
This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (National Healthcare Group, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.
Last updated on Oct 2022
This article was last reviewed on
Thursday, January 12, 2023
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