Ribociclib

Medication Information Leaflet

​What is this medication for?

Ribociclib is used to treat hormone-positive breast cancer that has spread to other parts of the body. It is used together with other medications such as Letrozole, Exemestane or Fulvestrant.

How should I take/use this medication?

  • Take Ribociclib once a day for 3 weeks, followed by 1 week of rest, in a 4-week cycle.
  • You can take it with or without food.
  • Do not break, chew or crush the tablet. Swallow the tablet whole.
    •  Inform your doctor or pharmacist if you have difficulty swallowing.

What should I do if I forget to take/use this medication?

If you forget to take a dose, skip the missed dose and take your next dose at the usual time. Do not take two doses at the same time to make up for the missed dose. 

What precautions should I take?

Inform your healthcare professional if: 
  • You are allergic to this medication
  • You or your partner becomes pregnant or is planning for pregnancy. 
    • You should use effective birth control during and for 3 weeks after stopping Ribociclib.
  • You are breastfeeding
    • Do not breastfeed during treatment
  • You have any other medical conditions such as heart disease

What are some common side-effects of this medication?

  • Nausea and vomiting
    • Take small, frequent meals throughout the day.
  • Decreased appetite
  • Diarrhea or constipation
    • To manage diarrhoea:
      • Drink plenty of clear fluids to replace those lost (2 litres everyday).
      • Avoid oily or spicy food and milk or dairy products.
    • To manage constipation:
      • Drink more water or clear fluids (if you do not have a limit on the amount that you can take each day).
      • Add more fibre to your diet by eating more fruits and vegetables.
  • Rash
    • Avoid taking hot showers. 
  • Hair loss
    • Use a gentle shampoo to wash your hair.
  • Feeling tired and lack of energy
    • Do not drive or operate machinery when you feel tired.
  • Headache 
  • Decreased white blood cells
    • This may put you at higher risk of infections.
    • To reduce your risk of infection:
      • Avoid crowds and people who are sick. Wear a face mask when you are going out.
      • Wash your hands after using the toilet and before handling food.
      • Eat food that is fresh and completely cooked, and avoid raw or half-cooked food.
If any of these side-effects are very bad, see your healthcare professional immediately.

What are some rare but serious side-effects that I need to seek medical advice immediately?

  • Signs of infection - fever of 38° C and above, chills, cough, sore throat, pain or burning feeling on passing urine
  • Unusual bleeding, bruising, black sticky stools or blood in urine
  • Cough with chest pain or breathing difficulty
  • Dark urine or light coloured stools, nausea, vomiting, loss of appetite, stomach pain, yellowing of your eyes or skin
  • Fast or irregular heartbeat, chest discomfort or if you feel faint, light-headed, or dizzy
The symptoms of a drug allergy include one or more of the following: 
  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body
If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

What food or medication should I avoid when I take this medication?

Avoid taking grapefruit and pomegranate when you are taking this medication as these may interact with your medication and increase the risk of side-effects.

Inform your healthcare professional if you are taking or intend to take any other medication, supplements, traditional medications or herbal remedies.


How should I store this medication?

Store in a cool and dry place, away from direct sunlight. Keep this medication away from children. 

How should I throw away this medication safely?

Pack Ribociclib into a bag and bring it back to the pharmacy where you received it from. 

You may refer to the following website if you need more information: https://www.macmillan.org.uk/ 


Disclaimers
If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.


This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (National Healthcare Group, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.

Last updated on September 2019
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Ribociclib

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