Donepezil is used to treat the symptoms of Alzheimer’s disease. It does not cure the disease and will not stop the disease from getting worse.


​What is this medication used for​​​

Donepezil is used to treat the symptoms of Alzheimer’s disease. It does not cure the disease and will not stop the disease from getting worse.

Donepezil is known as a cholinesterase inhibitor. It prevents the breakdown of acetylcholine, a chemical messenger in the brain, which is important for memory and other thinking skills. This keeps the levels of acetylcholine high, even while the brain cells that produce the messenger continue to become damaged or die. It works most effectively for people who have mild to moderate levels of Alzheimer’s disease.

Dosage and How to Use

  • Do not stop taking your medicines without checking with your doctors.
  • If you miss a dose, take the missed dose as soon as you remember. If it is almost time for your next dose, take only the usual dose. Do not double your dose or use extra medicine to make up for the missed dose.
  • The medicine can be taken with or without food.
  • ​Make sure your hands are dry before handling the tablet. Remove the tablet from the blister pack when you are ready to use it. The tablet should be placed on the tongue and allowed to be dissolved before swallowing. You can swallow the dissolved medicine with or without water.

Side Effects, Precautions, Contraindication​​​

What are the possible side effects of the medicine?​

The common side effects are nausea, vomiting, diarrhoea, insomnia, headache, tiredness, dizziness and muscle cramps.

How do I know if I am allergic to this medicine?​

The symptoms of a drug allergy include one or more of the following:

  • Swollen face/eyes/lips
  • Difficulty in breathing
  • ​Itchy skin rashes over your whole body

If you experience any of these symptoms, you should stop your medicine immediately and see your doctor.

What precautions should I follow when taking the medicine?

Inform your doctor if you have any of the following medical conditions before starting on Donepezil:

  • stomach or intestinal ulcers
  • fits
  • irregular or very slow heart beat
  • lung diseases such as asthma
  • severe liver disease
  • ​difficulty passing urine

Handling and Storage​​

  • Keep your medicines in the original container or packaging, tightly closed or sealed in a cool and dry place, away from direct sunlight.
  • ​Keep the medicine out of reach of children.
  • Throw away all expired medicines.
  • The recommended storage temperature is 15-30°C.
  • ​​The medicine should be kept intact in its blister pack until you start using it as the tablet might change colour when exposed to light.


Additional Infomation

Associated Brand Name:​​​​

Aricept Evess®

This article answers some common questions about this medicine. It does not contain all the available information. It also does not take the place of talking to your doctor or pharmacist.


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